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首页> 外文期刊>European review for medical and pharmacological sciences. >Interhemispheric functional and structural alterations and their relationships with alertness in unilateral temporal lobe epilepsy
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Interhemispheric functional and structural alterations and their relationships with alertness in unilateral temporal lobe epilepsy

机译:单侧颞叶癫痫的半球间功能和结构改变及其与机敏性的关系

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OBJECTIVE: Many neuroimaging studies have shown that temporal lobe epilepsy (TLE) is associated with functional and structural abnormalities at specific brain areas. Unfortunately, relatively limited information has been presented about the alterations of interhemispheric functional and anatomic connectivity in patients with unilateral TLE. In the present study, we investigated interhemispheric functional connectivity using a voxel-mirrored homotopic connectivity (VMHC) method. We further revealed fractional anisotropy (FA) changes in the areas with abnormal VMHC values in TLE patients by diffusion tensor imaging (DTI). Moreover, their relationships with alertness in patients with drug-naive unilateral TLE were also investigated.
机译:目的:许多神经影像学研究表明颞叶癫痫(TLE)与特定大脑区域的功能和结构异常有关。不幸的是,关于单侧TLE患者的半球间功能和解剖学连接改变的信息相对有限。在本研究中,我们使用体素镜像同位连接(VMHC)方法研究了半球之间的功能连接。我们进一步通过弥散张量成像(DTI)揭示了TLE患者VMHC值异常的区域中的分数各向异性(FA)变化。此外,还研究了他们与未经药物治疗的单侧TLE患者警觉性的关系。

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