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首页> 外文期刊>European journal of preventive cardiology >Comparable short-term prognosis in diabetic and non-diabetic patients with acute coronary syndrome after cardiac rehabilitation.
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Comparable short-term prognosis in diabetic and non-diabetic patients with acute coronary syndrome after cardiac rehabilitation.

机译:心脏康复后,糖尿病和非糖尿病合并急性冠脉综合征的短期预后相当。

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Patients with pathological glucometabolism are at increased risk of recurrent cardiovascular events after acute coronary syndrome (ACS). The goal of this study was to investigate the association of glucometabolism and the one-year outcome of cardiac rehabilitation patients.Prospective multicentre registry from four German rehabilitation clinics.During 2005-2006, 1614 consecutive patients (85.9% male, mean age 55?±?10.3 years) were included after the first ACS (mean 18.9 days) and classified into group 1 (apparent diabetes mellitus, n?=?268), group 2 (no diabetes, impaired oral glucose tolerance [OGT], n?=?185), and group 3 (normal fasting glucose and normal OGT, n?=?1161). The mean follow-up was 13.4 months and the follow-up events were analysed by multivariate logistic regression models with backward elimination.The overall mortality was 1.3% (group 1: 1.2%; group 2: 1.8%; group 3: 1.5%; p(Trend)?=?NS). The target blood pressure values at discharge (<140/90?mmHg) were achieved by 88.7%, 89.1% and 90.8% of patients in groups 1, 2 and 3, respectively (p(Trend)?=?NS). The target value for LDL cholesterol (<100?mg/dl) was attained by 87.0%, 80.8% and 81.5% of the patients in groups 1, 2 and 3, respectively (p(Trend)?=?NS). There was a trend of a lower proportion of patients reaching the target values for HDL-C of 46.1%, 51.4% and 60.8% (p(Trend)?
机译:患有病理性糖代谢的患者在急性冠状动脉综合征(ACS)后复发性心血管事件的风险增加。这项研究的目的是调查糖代谢与心脏康复患者一年结局的关系。来自德国四家康复诊所的前瞻性多中心登记。2005-2006年期间,连续1614例患者(男性85.9%,平均年龄55?±首次ACS后(平均18.9天)纳入[10.3岁],分为1组(表观糖尿病,n = 268),2组(无糖尿病,口服葡萄糖耐量[OGT]受损,n = 6)。 185)和第3组(正常的空腹血糖和正常的OGT,n == 1161)。平均随访时间为13.4个月,并采用具有后向消除功能的多变量Logistic回归模型对随访事件进行了分析。总死亡率为1.3%(组1:1.2%;组2:1.8%;组3:1.5%;组1:2)。 p(趋势)?=?NS)。第1、2和3组的患者出院时的目标血压值(<140/90?mmHg)分别达到88.7%,89.1%和90.8%(p(趋势)?=?NS)。第1、2和3组中分别达到87.0%,80.8%和81.5%患者的LDL胆固醇目标值(<100?mg / dl)(p(趋势)?=?NS)。趋势是达到HDL-C的目标值的患者的比例更低,分别为46.1%,51.4%和60.8%(p(趋势)≤0.001)和甘油三酸酯的达到65.1%,79.9%和74.6%(p第1、2和3组的(趋势)≤0.004)。总体死亡率最强的多元预测因子是经历过中风的患者(OR为6.29 [95%CI:1.06-37.19]; p?=?0.042),并且有趋势的是外周动脉疾病(OR为3.60 [95%CI :0.95-13.68];p≤0.061)。在多变量分析中,糖尿病状态与不良预后无关(即死亡或再次住院)。糖尿病和非糖尿病患者的短期预后均良好,并由终末器官损害而非糖代谢状态决定。糖尿病患者接受了可比的(而不是更具侵略性的)药物治疗,因此与非糖尿病和糖尿病前期患者相比,心血管疾病危险因素的目标值实现程度较低。

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