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首页> 外文期刊>Biochemical Pharmacology >RNA-binding protein-mediated post-transcriptional controls of gene expression: Integration of molecular mechanisms at the 3′ end of mRNAs?
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RNA-binding protein-mediated post-transcriptional controls of gene expression: Integration of molecular mechanisms at the 3′ end of mRNAs?

机译：RNA结合蛋白介导的基因表达的转录后控制：在mRNA的3'端整合分子机制？

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摘要

Initially identified as an occasional and peculiar mode of gene regulation in eukaryotes, RNA-binding protein-mediated post-transcriptional control of gene expression has emerged, over the last two decades, as a major contributor in the control of gene expression. A large variety of RNA-binding proteins (RBPs) allows the recognition of very diverse messenger RNA sequences and participates in the regulation of basically all cellular processes. Nevertheless, the rapid outcome of post-transcriptional regulations on the level of gene expression has favored the expansion of this type of regulation in cellular processes prone to rapid and frequent modulations such as the control of the inflammatory response. At the molecular level, the 3′untranslated region (3′UTR) of mRNA is a favored site of RBP recruitment. RBPs binding to these regions control gene expression through two major modes of regulation, namely mRNA decay and modulation of translational activity. Recent progresses suggest that these two mechanisms are often interdependent and might result one from the other. Therefore, different RBPs binding distinct RNA subsets could share similar modes of action at the molecular level. RBPs are frequent targets of post-translational modifications, thereby disclosing numerous possibilities for pharmacological interventions. However, redundancies of the transduction pathways controlling these modifications have limited the perspectives to define RBPs as new therapeutic targets. Through the analysis of several examples of RBPs binding to 3′Untranslated Region of mRNA, we present here recent progress and perspectives regarding this rapidly evolving field of molecular biology.
机译：最初被确定为真核生物中基因调节的一种偶然且独特的模式，在过去的二十年中，RNA结合蛋白介导的基因表达的转录后控制已经出现，成为基因表达控制的主要贡献者。各种各样的RNA结合蛋白（RBP）允许识别非常多样的信使RNA序列，并参与基本所有细胞过程的调控。然而，转录后调控对基因表达水平的快速结果有利于这种调控类型在易于快速和频繁调节例如炎症反应控制的细胞过程中的扩展。在分子水平上，mRNA的3'非翻译区（3'UTR）是RBP募集的有利位点。与这些区域结合的RBP通过两种主要的调节模式控制基因表达，即mRNA衰减和翻译活性调节。最近的进展表明，这两种机制通常是相互依赖的，并且可能是彼此产生的。因此，结合不同RNA亚组的不同RBP可以在分子水平上共享相似的作用方式。 RBP经常是翻译后修饰的靶标，从而公开了许多药理干预的可能性。但是，控制这些修饰的转导途径的冗余性限制了将RBP定义为新治疗靶点的观点。通过分析RBP与mRNA 3'非翻译区结合的几个实例，我们在此介绍了分子生物学这一快速发展领域的最新进展和观点。

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