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首页> 外文期刊>European psychiatry: the journal of the Association of European Psychiatrists >Fast versus slow onset of depressive episodes: A clinical criterion for subtyping patients with major depression
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Fast versus slow onset of depressive episodes: A clinical criterion for subtyping patients with major depression

机译：抑郁发作的快与慢发作：重度抑郁患者亚型的临床标准

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Purpose: The speed of onset of depressive episodes is a clinical aspect of affective disorders that has not been sufficiently investigated. Thus, we aimed to explore whether patients with fast onset of the full-blown depressive symptomatology (≤ 7 days) differ from those with slow onset (> 7 days) with regard to demographic and clinical aspects. Subjects and methods: Data were obtained within an observational study conducted in outpatients with major depression who were treated with duloxetine (30-120. mg/day). Onset of depression (without any preceding critical life event) was fast in 416 (less than one week) and slower in 2220 patients. Results: Compared to patients with slow onset, those with fast onset of depression had more suicide attempts in the previous 12 months (2.7% versus 1.3%, P= 0.046) and less somatic comorbidity (61.7% versus 74.1%, P< 0.0001). In addition, they were slightly younger at onset of depression (mean ± SD 40.2 ± 14.6 versus 42.8 ± 14.2 years, P< 0.001) and used analgesics at baseline significantly less frequently (22.8% versus 33.4%, P< 0.0001). Discussion and conclusion: The speed of onset of depression has to be regarded as a relevant clinical characteristic in patients with unipolar depression.
机译：目的：抑郁发作的速度是情感障碍的临床方面，尚未得到充分研究。因此，我们旨在探讨在抑郁症的人口统计学和临床​​方面，快速发作的成熟抑郁症状患者（≤7天）与缓慢发作的患者（> 7天）是否有所不同。受试者和方法：数据来自对接受度洛西汀（30-120。mg /天）治疗的重度抑郁症门诊患者的观察研究。抑郁症的发作（没有任何之前的危急生命事件）在416例（少于一周）内很快，而在2220例患者中较慢。结果：与缓慢发作的患者相比，快速发作的抑郁症患者在过去的12个月内自杀尝试次数更多（2.7％对1.3％，P = 0.046）和体格合并症更少（61.7％对74.1％，P <0.0001） 。此外，他们在抑郁发作时年龄稍小（平均±SD 40.2±14.6与42.8±14.2岁，P <0.001），并且在基线时使用镇痛药的频率明显降低（22.8％对33.4％，P <0.0001）。讨论和结论：对于单相抑郁症患者，抑郁症的发作速度必须被视为相关的临床特征。

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