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Fronto-limbic disconnection in bipolar disorder

机译:双相情感障碍的额-边缘切断

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摘要

Background: Bipolar disorder (BD) is a severe, disabling and life-threatening illness. Disturbances in emotion and affective processing are core features of the disorder with affective instability being paralleled by mood-congruent biases in information processing that influence evaluative processes and social judgment. Several lines of evidence, coming from neuropsychological and imaging studies, suggest that disrupted neural connectivity could play a role in the mechanistic explanation of these cognitive and emotional symptoms. The aim of the present study is to investigate the effective connectivity in a sample of bipolar patients.
机译:背景:躁郁症(BD)是一种严重的致残性疾病,危及生命。情绪和情感处理中的干扰是该障碍的核心特征,情感不稳定性与影响评估过程和社会判断的信息处理中与情绪一致的偏向并存。来自神经心理学和影像学研究的几条证据表明,神经连通性的破坏可能在这些认知和情感症状的机械解释中起作用。本研究的目的是调查双相患者样本中的有效连通性。

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