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首页> 外文期刊>Expert Review of Molecular Diagnostics >QuantiFERON(R)-CMV assay for the assessment of cytomegalovirus cell-mediated immunity.
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QuantiFERON(R)-CMV assay for the assessment of cytomegalovirus cell-mediated immunity.

机译：用于评估巨细胞病毒细胞介导的免疫力的QuantiFERON（R）-CMV分析。

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Cytomegalovirus (CMV) infection has historically been a major complication among immunocompromised patients, such as solid-organ and stem-cell transplant recipients and patients with advanced HIV infection. While the introduction of antiretroviral therapy has almost eradicated CMV infection in HIV-infected patients, CMV disease remains a significant problem in transplant recipients once antiviral prophylaxis is discontinued. QuantiFERON((R))-CMV allows the assessment of cellular immunity against CMV by detecting the production of IFN-gamma following in vitro stimulation with CMV antigens. Preliminary studies have shown a correlation between a lack of detectable cell-mediated immunity measured by the QuantiFERON-CMV assay and a higher incidence of CMV infection and disease in immunocompromised patients. Measurement of cell-mediated immunity against CMV appears to be a promising strategy to identify patients at highest risk for the development of CMV disease and, therefore, to individualize preventive strategies for CMV in transplant recipients.
机译：巨细胞病毒（CMV）感染历来是免疫受损患者（如实体器官和干细胞移植受者以及晚期HIV感染患者）的主要并发症。虽然抗逆转录病毒疗法的引入几乎消除了HIV感染患者的CMV感染，但一旦中止抗病毒预防，CMV疾病仍然是移植受者中的重大问题。通过在体外用CMV抗原刺激后检测IFN-γ的产生，QuantiFERON-CMV允许评估针对CMV的细胞免疫性。初步研究表明，在QuantitFERON-CMV分析中检测不到可检测的细胞介导的免疫力与免疫受损患者中CMV感染和疾病发生率较高之间存在相关性。测量细胞介导的针对CMV的免疫力似乎是一种有前途的策略，可以识别出发生CMV疾病风险最高的患者，因此，可以针对移植接受者个体化CMV的预防策略。

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