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首页> 外文期刊>Expert Review of Molecular Diagnostics >Insights revealed by high-throughput genomic arrays in nonglial primary brain tumors
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Insights revealed by high-throughput genomic arrays in nonglial primary brain tumors

机译：非神经胶质原发性脑肿瘤中高通量基因组阵列揭示的见解

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摘要

Primary CNS tumors (PCNSTs) encompass a broad and heterogeneous group of tumors, including gliomas, meningiomas, embryonal tumors, primary CNS lymphomas, CNS germ cell tumors and sellar region tumors. In recent decades, research has focused on understanding the clinical and biological significance of molecular abnormalities detected in PCNSTs. The emergence of genomic arrays, including comparative genomic hybridization and SNP arrays, have helped in the discovery of novel critically important genes and novel genomic biomarkers involved in PCNST oncogenesis (e.g., BRAF duplication in pilocytic astrocytoma). Since a summary of data from genomic arrays using gliomas has been described in a previous review, in this article we will focus on the insights provided by genome-wide DNA arrays in the genetics and genomics of nonglial PCNSTs in adults. The high-throughput assessment of gene copy-number abnormalities has improved our knowledge of molecular pathogenesis in nonglial PCNSTs, allowing for the identification of new candidate genomic regions and genes involved in tumorigenesis. These chromosome imbalances provide a promising insight into potential targets for innovative drugs and new interesting diagnostic and prognostic biomarkers for clinical practice.
机译：中枢神经系统原发肿瘤（PCNST）涵盖了广泛而异类的肿瘤，包括神经胶质瘤，脑膜瘤，胚胎肿瘤，中枢神经系统淋巴瘤，中枢神经系统生殖细胞肿瘤和鞍区肿瘤。近几十年来，研究集中在理解PCNST中检测到的分子异常的临床和生物学意义。基因组阵列的出现，包括比较基因组杂交和SNP阵列，已经帮助发现了与PCNST肿瘤发生有关的新的至关重要的基因和新的基因组生物标志物（例如，毛细胞星形细胞瘤中的BRAF复制）。由于在先前的综述中已经描述了使用神经胶质瘤从基因组阵列获得的数据摘要，因此在本文中，我们将重点关注全基因组DNA阵列在成人非胶质PCNST的遗传学和基因组学中提供的见解。基因拷贝数异常的高通量评估提高了我们对非神经胶质PCNSTs分子发病机制的了解，从而有助于鉴定新的候选基因组区域和参与肿瘤发生的基因。这些染色体失衡为创新药物的潜在靶标以及临床实践中新的有趣的诊断和预后生物标志物提供了有希望的见解。

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