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首页> 外文期刊>Expert Review of Molecular Diagnostics >Functional drug-gene interactions in lung cancer
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Functional drug-gene interactions in lung cancer

机译：肺癌中的功能性药物基因相互作用

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Despite the dawn of the genomic information era, the challenges of cancer treatment remain formidable. Particularly for the most prevalent cancer types, including lung cancer, successful treatment of metastatic disease is rare and escalating costs for modern targeted drugs place an increasing strain on healthcare systems. Although powerful diagnostic tools to characterize individual tumor samples in great molecular detail are becoming rapidly available, the transformation of this information into therapy provides a major challenge. A fundamental difficulty is the molecular complexity of cancer cells that often causes drug resistance, but can also render tumors exquisitely sensitive to targeted agents. By using lung cancer as an example, we outline the principles that govern drug sensitivity and resistance from a genetic perspective and discuss how in vitro chemical-genetic screens can impact on patient stratification in the clinic.
机译：尽管基因组信息时代已经来临，但是癌症治疗的挑战仍然艰巨。特别是对于包括肺癌在内的最普遍的癌症类型，成功治疗转移性疾病的情况很少，而现代靶向药物的成本不断上涨给医疗保健系统带来了越来越大的压力。尽管功能强大的诊断工具可以详细地描述单个肿瘤样本的分子细节，但这种信息的转化已成为一项重大挑战。一个基本的困难是癌细胞的分子复杂性，通常会引起耐药性，但也会使肿瘤对靶向药物非常敏感。以肺癌为例，我们从遗传学角度概述了控制药物敏感性和耐药性的原则，并讨论了体外化学遗传筛选如何影响临床中的患者分层。

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