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首页> 外文期刊>Expert Review of Molecular Diagnostics >Breast cancer stem cell enrichment and isolation by mammosphere culture and its potential diagnostic applications
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Breast cancer stem cell enrichment and isolation by mammosphere culture and its potential diagnostic applications

机译：乳球培养富集和分离乳腺癌干细胞及其潜在诊断应用

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摘要

Emerging knowledge about cancer stem cells (CSCs) is raising attention about the need to provide a more precise and complete diagnosis including the molecular profile of a patient's CSCs. As opposed to simply treating the bulk of the tumor, a more complete diagnosis can lead to treatment regimens designed to eradicate CSCs from a patient. In this review the authors detail the application of the mammosphere assay in the study of breast CSCs. The authors then describe the potential transition of the mammosphere assay from the research laboratory to the clinic by leveraging microsystems technology, which enables the integration of multiple functions into a single automated device. To conclude the review, the authors project that future clinical devices will be capable of isolating circulating metastatic cells from patient blood, enriching the dangerous CSCs, and providing a molecular profile of the CSCs, thus arming physicians with the information to select a treatment program that combats CSCs.
机译：关于癌症干细胞（CSC）的新兴知识引起人们对提供更精确和完整诊断包括患者CSC分子概况的需求的关注。与简单地治疗大部分肿瘤相反，更完整的诊断可以导致设计出从患者根除CSC的治疗方案。在这篇综述中，作者详细介绍了乳球测定法在乳腺CSC研究中的应用。然后，作者描述了利用微系统技术进行的乳球测定法从研究实验室到临床的潜在转变，该技术可使多种功能集成到单个自动化设备中。作为总结，作者预测未来的临床设备将能够从患者血液中分离循环转移细胞，富集危险的CSC，并提供CSC的分子概况，从而使医生掌握选择治疗方案所需的信息。与CSC作战。

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