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首页> 外文期刊>Expert Review of Molecular Diagnostics >Limitations of typhoid fever diagnostics and the need for prevention
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Limitations of typhoid fever diagnostics and the need for prevention

机译：伤寒诊断的局限性和预防的需要

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摘要

The study under review evaluated serological tests for typhoid fever against PCR as a reference test. While laboratory testing is essential for the confirmation of this severe disease, the low bacterial load and the low level of specific antibodies in the blood of typhoid patients combined with its acute character make interpretation of laboratory testing cumbersome. Validation of an index test requires good understanding of the diagnostic performance and assay characteristics of the reference test, and criteria and principles for study design and reporting outlined by the Quality Assessment of Diagnostic Accuracy Studies and the Standards for Reporting Studies of Diagnostic Accuracy should be followed. Described PCR assays for typhoid fever have not been validated against bone marrow culture, the gold standard, and their diagnostic utility remains to be established.
机译：所审查的研究评估了针对PCR的伤寒血清学检测作为参考检测。虽然实验室测试对于确认这种严重疾病至关重要，但伤寒患者血液中细菌含量低，特异性抗体水平低以及其急性特征使得对实验室测试的解释变得繁琐。指标测试的验证需要对参考测试的诊断性能和测定特性有充分的了解，并且应遵循诊断准确性研究质量评估和诊断准确性报告研究标准概述的研究设计和报告标准和原则。尚未描述针对伤寒的PCR检测方法是否针对骨髓培养物（黄金标准）进行了验证，其诊断用途仍有待建立。

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