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首页> 外文期刊>Expert Review of Molecular Diagnostics >Contributions and future perspectives on the use of magnetic nanoparticles as diagnostic and therapeutic tools in the field of regenerative medicine
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Contributions and future perspectives on the use of magnetic nanoparticles as diagnostic and therapeutic tools in the field of regenerative medicine

机译：关于磁性纳米粒子在再生医学领域中作为诊断和治疗工具的应用的贡献和未来展望

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The current limitations of regenerative medicine strategies may be overcome through the use of magnetic nanoparticles (MNPs), a class of nanomaterial typically composed of magnetic elements that can be manipulated under the influence of an external magnetic field. Cell engineering approaches following the internalization of these MNPs by cells and/or the incorporation of these nanosystems within 3D constructs (scaffolds or hydrogels) may constitute a new attractive approach to achieve a magnetically responsive system enabling remote control over tissue-engineered constructs in an in vivo scenario. Moreover, the incorporation of bioactive factors within these MNPs also enables a targeted and smart delivery of biomolecules to specific regions and/or triggering specific cell responses upon external magnetic stimulation. Certainly, one of the most attractive properties of MNPs is their ability to be used as theranostic tools for regenerative medicine applications, enabling live monitoring and tracking of the system while simultaneously acting as a therapeutic stimulation.
机译：再生医学策略的当前局限性可以通过使用磁性纳米颗粒（MNP）来克服，磁性纳米颗粒（MNP）是一类通常由磁性元素组成的纳米材料，可以在外部磁场的影响下对其进行操作。细胞将这些MNP内在化和/或将这些纳米系统并入3D构建体（支架或水凝胶）后的细胞工程方法可能构成一种新的有吸引力的方法，以实现磁响应系统，从而能够对组织中的组织工程构建体进行远程控制。体内场景。此外，将生物活性因子掺入这些MNP中还使得能够将生物分子靶向和智能地递送至特定区域和/或在外部磁刺激时触发特定细胞应答。当然，MNP的最吸引人的特性之一是它们可用作再生医学应用的治疗诊断工具的能力，既可以实时监控和跟踪系统，同时又可以作为治疗刺激。

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