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首页> 外文期刊>Expert Review of Molecular Diagnostics >Epigenetic-mediated tumor suppressor genes as diagnostic or prognostic biomarkers in gastric cancer
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Epigenetic-mediated tumor suppressor genes as diagnostic or prognostic biomarkers in gastric cancer

机译：表观遗传介导的抑癌基因作为胃癌的诊断或预后生物标志物

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摘要

Gastric cancer is believed to result in part from the accumulation of multiple genetic and epigenetic alterations leading to oncogene overexpression and tumor suppressor loss. Tumor suppressor genes are inactivated more frequently by promoter methylation than by mutation in gastric cancer. Identification of genes inactivated by promoter methylation is a powerful approach to discover novel tumor suppressor genes. We have previously identified tumor suppressor genes in gastric cancer by genome-wide methylation screening. The biological functions of these genes are related to cell adhesion, ubiquitination, transcription, p53 regulation and diverse signaling pathways. Some of the tumor suppressor genes are of particular clinical importance as they can be used as predictive biomarkers for early diagnosis or ongoing prognosis of gastric cancer.
机译：据信胃癌部分是由于多种遗传和表观遗传学改变的积累导致的，致癌基因的过表达和肿瘤抑制因子的丧失。在胃癌中，抑癌基因被启动子甲基化灭活的频率高于突变。通过启动子甲基化灭活的基因的鉴定是发现新型肿瘤抑制基因的有效方法。我们以前已经通过全基因组甲基化筛选在胃癌中发现了肿瘤抑制基因。这些基因的生物学功能与细胞粘附，泛素化，转录，p53调控和多种信号通路有关。一些肿瘤抑制基因具有特殊的临床意义，因为它们可用作胃癌早期诊断或预后的预测性生物标志物。

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