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首页> 外文期刊>Expert Review of Molecular Diagnostics >Selected culture and drug-susceptibility testing methods for drug-resistant Mycobacterium tuberculosis screening in resource-constrained settings.
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Selected culture and drug-susceptibility testing methods for drug-resistant Mycobacterium tuberculosis screening in resource-constrained settings.

机译：在资源有限的环境中筛选耐药性结核分枝杆菌的选定培养物和药物敏感性测试方法。

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Evaluation of: Adikaram CP, Perera J, Wijesundera SS. The manual Mycobacteria Growth Indicator Tube and the Nitrate Reductase Assay for the rapid detection of rifampicin resistance of M. tuberculosis in low resource settings. BMC Infect. Dis. 12, 326 (2012). The control of drug-resistant tuberculosis (TB) requires an accurate and a rapid diagnostic for the detection of critical patterns of drug resistance. Rifampicin resistance is a good predictor of the presence of multidrug-resistant TB. Traditionally, in?vitro susceptibility methods for Mycobacterium tuberculosis are time consuming and laborious. More rapid methods are available but are very expensive for routine use in low-resource settings. According to the article under evaluation, the Manual Mycobacteria Growth Indicator Tube and Nitrate Reductase Assay, in liquid medium, agreed well with the agar proportion method for the rapid detection of rifampicin resistance in low-resource settings. The results of both susceptibility tests will be available in less than 2 weeks and the cost per test is low. Major efforts are needed to improve the diagnostic and treatment success rate among patients with drug-resistant TB. Since 2007, the WHO has promoted new diagnostic tests such as Xpert Mycobacterium tuberculosis/rifampicin; point-of-care tests are nowadays under development.
机译：评价：Adikaram CP，Perera J，Wijesundera SS。手动分枝杆菌生长指示剂管和硝酸还原酶测定法，用于在资源贫乏地区快速检测结核分枝杆菌的利福平耐药性。 BMC感染。 Dis。 12，326（2012）。耐药性结核病（TB）的控制要求准确，快速的诊断，以检测耐药性的关键模式。利福平的耐药性可以很好地预测耐多药结核病的发生。传统上，结核分枝杆菌的体外药敏方法既费时又费力。可以使用更快速的方法，但是在资源匮乏的环境中常规使用非常昂贵。根据被评估的文章，在液体培养基中进行的《手动分枝杆菌生长指示剂管和硝酸还原酶测定法》与琼脂比例法在资源贫乏地区快速检测利福平耐药性非常吻合。两种药敏试验的结果将在不到2周的时间内获得，而且每次试验的成本很低。需要做出很大的努力来提高耐药结核病患者的诊断和治疗成功率。自2007年以来，WHO促进了新的诊断测试，例如Xpert结核分枝杆菌/利福平;即时检验目前正在开发中。

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