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首页> 外文期刊>Burns: Including Thermal Injury >The time-related changes of antimicrobial resistance patterns and predominant bacterial profiles of burn wounds and body flora of burned patients.
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The time-related changes of antimicrobial resistance patterns and predominant bacterial profiles of burn wounds and body flora of burned patients.

机译：烧伤患者的伤口和身体菌群的抗菌素耐药性模式和主要细菌特征随时间的变化。

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To examine the bacterial isolates from the burn patients and to compare the antibiograms of the predominant bacteria isolated from 51 patients who were hospitalized at least 3 weeks or more over a period of 7 months, a prospective study was undertaken. Periodic swabs were taken from burn wound, nasal, axillary, inguinal, and umblical region of the patients on admission and on 7th, 14th, and 21st days of hospitalization. Mean hospital stay was 36.5 days. A total of 1098 microbial isolates were detected during the study period. Coagulase-negative staphylococci (CNS, 63.0%) and Staphylococcus aureus (19.7%) were the most prevalent isolates in admission cultures. During the next weeks, these bacteria were superceded by mainly Pseudomonas aeruginosa. Between admission and 21st day, the rates of methicillin resistance of staphylococci strains increased steadily. There was no vancomycin resistance in any staphylococci strains, although nine of the S. aureus isolates (2.7%) were resistant to teicoplanin. Therewere no strains producing inducible beta lactamase (IBL) among P. aeruginosa strains. One extended-spectrum beta-lactamase (ESBL)-producing strain was recovered on admission, although strains producing IBL and ESBL were detected at rates of 79.6 and 57.1%, respectively, on the 21st day. The nature of microbial wound colonization, flora changes, and antimicrobial sensitivity profiles should be taken into consideration in using empirical antimicrobial therapy of burned patients.
机译：为了检查烧伤患者的细菌分离物并比较从51例住院患者中分离出的主要细菌的抗菌素谱图，这些患者在7个月内住院至少3周或更长时间，进行了前瞻性研究。在入院时以及住院的第7、14和21天，从患者的烧伤伤口，鼻，腋窝，腹股沟和脐带定期采集拭子。平均住院时间为36.5天。在研究期间共检测到1098株微生物。凝固酶阴性葡萄球菌（CNS，63.0％）和金黄色葡萄球菌（19.7％）是进入培养物中最流行的分离株。在接下来的几周中，这些细菌主要被铜绿假单胞菌所取代。在入院至第21天之间，葡萄球菌菌株对甲氧西林的耐药率稳步上升。尽管有9株金黄色葡萄球菌（2.7％）对替考拉宁耐药，但在任何葡萄球菌菌株中均无万古霉素耐药性。在铜绿假单胞菌菌株中没有产生可诱导的β-内酰胺酶（IBL）的菌株。入院时回收了一株产广谱β-内酰胺酶（ESBL）的菌株，尽管在第21天检出产IBL和ESBL的菌株的比率分别为79.6％和57.1％。在使用烧伤患者的经验性抗菌疗法时，应考虑微生物伤口定植，菌群变化和抗菌敏感性分布的性质。

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