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首页> 外文期刊>Burns: Including Thermal Injury >Effect of ablated airway blood flow on systemic and pulmonary microvascular permeability after smoke inhalation in sheep.
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Effect of ablated airway blood flow on systemic and pulmonary microvascular permeability after smoke inhalation in sheep.

机译：绵羊烟气吸入后气道血流量减少对全身和肺微血管通透性的影响。

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摘要

The bronchial circulation plays a significant role in the pathogenesis of smoke inhalation. We investigated the physiological manifestations in both the systemic and the pulmonary circulation after smoke inhalation injury, and determined whether ablation of the bronchial circulation had any effect on these changes. We used a chronically instrumented ovine model with lung and prefemoral lymph fistulae to determine the changes in pulmonary and systemic microvascular permeability. Fourteen animals were divided into two groups. The injection group had bronchial circulation ablation with an ethanol injection into the bronchial artery, whereas it was left intact in the sham group. The sham group showed a four-fold increase in lung lymph flow (l-Q(L)) and a two-fold increase in prefemoral lymph flow (s-Q(L)) 24 h after injury. The increase in s-Q(L) was associated with a decrease in lymph oncotic pressure. Therefore, systemic colloid clearance (s-CC), an indicator of systemic microvascular permeability to protein, was unchanged. The ablated bronchial circulation reversed the pulmonary but not the systemic manifestations after smoke inhalation. In conclusion, the pathophysiological events occurring after smoke inhalation were confined to the lung with increased bronchial blood flow delivering inflammatory mediators directly to the lung parenchyma.
机译：支气管循环在烟雾吸入的发病机理中起重要作用。我们调查了烟雾吸入损伤后在全身和肺循环中的生理表现，并确定了消融支气管循环是否对这些变化有任何影响。我们使用具有肺和股前淋巴瘘管的慢性仪器化羊模型来确定肺和全身微血管通透性的变化。将十四只动物分为两组。注射组在向支气管动脉中注射乙醇后进行了支气管循环消融，而在假手术组中则完好无损。假手术组在伤后24小时肺淋巴流量（l-Q（L））增加了4倍，股前淋巴流量（s-Q（L））增加了2倍。 s-Q（L）的增加与淋巴液渗透压的降低有关。因此，全身胶体清除率（s-CC），即全身微血管对蛋白质的渗透性的指标，没有改变。烟气吸入后，消融的支气管循环逆转了肺部而非全身性表现。总之，吸入烟后发生的病理生理事件仅限于肺，支气管血流量增加将炎症介质直接传递到肺实质。

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