...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Experimental Biology and Medicine: Journal of the Society for Experimental Biology and Medicine >Sulforaphane attenuates the development of atherosclerosis and improves endothelial dysfunction in hypercholesterolemic rabbits
【24h】

Sulforaphane attenuates the development of atherosclerosis and improves endothelial dysfunction in hypercholesterolemic rabbits

机译：萝卜硫素减轻高胆固醇血症兔的动脉粥样硬化发展并改善其内皮功能障碍

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of the present work was to explore possible protective effects of sulforaphane (SFN) against atherosclerosis development and endothelial dysfunction in hypercholesterolemic rabbits. Rabbits were assigned to three groups of five: group I fed normal chow diet for four weeks, group II fed 1% high cholesterol diet (HCD) and group III fed HCD+SFN (0.25 mg/kg/day). Blood samples were collected for measurement of serum triglycerides (TGs), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), lactate dehydrogenase (LDH) and C-reactive protein (CRP). Aortic malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and total nitriteitrate (NOx) were measured. Vascular reactivity and intima/media (I/M) ratio were analyzed. Nuclear factor-kappa B (NF-kappa B) activation in aortic endothelial cells was identified immunohistochemically. HCD induced significant increases in serum TGs, TC, LDL-C, LDH, and CRP, and aortic MDA and SOD. Moreover, HCD caused significant reductions in serum HDL-C, aortic GSH and NOx. SFN administration significantly decreased HCD-induced elevations in serum TC, LDL-C, CRP, and LDH. while significantly increased HDL-C and GSH levels and normalized aortic SOD and NOx. Additionally, SFN significantly improved rabbit aortic endothelium-dependent relaxation to acetylcholine. Moreover, SFN significantly reduced the elevation in I/M ratio. This effect was confirmed by aortic histopathologic examination. The expression of NF-kappa B in aortic tissue showed a marked reduction upon treatment with SFN. In conclusion, this study reveals that SFN has the ability to ameliorate HCD-induced atherosclerotic lesions progression and vascular dysfunction, possibly via its lipid-lowering and antioxidant effects and suppression of NF-kappa B-mediated inflammation.
机译：本工作的目的是探讨萝卜硫烷（SFN）对高胆固醇血症兔的动脉粥样硬化发展和内皮功能障碍的可能的保护作用。将兔子分为三组，每组五组：第一组喂食正常食物四个星期，第二组喂食1％高胆固醇饮食（HCD），第三组喂食HCD + SFN（0.25 mg / kg /天）。收集血液样本以测量血清甘油三酸酯（TGs），总胆固醇（TC），高密度脂蛋白胆固醇（HDL-C），乳酸脱氢酶（LDH）和C反应蛋白（CRP）。测量了主动脉丙二醛（MDA），还原型谷胱甘肽（GSH），超氧化物歧化酶（SOD）和总亚硝酸盐/硝酸盐（NOx）。分析血管反应性和内膜/中膜（I / M）比。免疫组织化学方法鉴定了主动脉内皮细胞中的核因子-κB（NF-κB）活化。 HCD诱导血清TG，TC，LDL-C，LDH和CRP以及主动脉MDA和SOD显着增加。此外，HCD导致血清HDL-C，主动脉GSH和NOx明显降低。 SFN给药显着降低了HCD诱导的血清TC，LDL-C，CRP和LDH升高。同时显着增加HDL-C和GSH水平，并使主动脉SOD和NOx标准化。另外，SFN显着改善了兔主动脉内皮依赖性对乙酰胆碱的松弛。此外，SFN大大降低了I / M比的提高。主动脉组织病理学检查证实了该作用。经SFN处理后，主动脉组织中NF-κB的表达显着降低。总之，这项研究表明，SFN可能通过其降脂和抗氧化作用以及抑制NF-κB介导的炎症来改善HCD诱导的动脉粥样硬化病变进展和血管功能障碍。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号