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首页> 外文期刊>Experimental Brain Research >Heterogeneity of the developmental patterns of neurotrophin protein levels among neocortical areas of macaque monkeys.
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Heterogeneity of the developmental patterns of neurotrophin protein levels among neocortical areas of macaque monkeys.

机译：猕猴新皮层区域中神经营养蛋白水平的发育模式的异质性。

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摘要

Based on morphological and physiological characteristics, the mammalian neocortex is divided into various neocortical areas and its diversity is prominent in the primates including humans. These neocortical areas are constructed during development, but the details of the developmental events remain unclear, especially at the molecular level. We measured the mRNA and protein levels of neurotrophins in various neocortical areas of developing rhesus monkeys. The expression patterns of both the neurotrophin-3 (NT-3) mRNA and the protein showed area differences. In the sensory and motor areas, NT-3 mRNA and protein levels had started to decline by a week after birth. In contrast, the levels declined after the third postnatal week in the association neocortical areas. The level of brain-derived neurotrophic factor (BDNF) protein changed in an area-dependent manner during development, but that of mRNA did not. The decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas, suggesting that sensory and motor neocortical areas develop earlier than the association areas in terms of the developmental changes in neurotrophins.
机译：根据形态和生理特征，哺乳动物新皮层被划分为不同的新皮层区域，并且其多样性在包括人类在内的灵长类动物中都非常突出。这些新皮质区域是在发育过程中构建的，但发育事件的细节仍然不清楚，尤其是在分子水平上。我们在发育中的恒河猴的各个新皮质区域测量了神经营养蛋白的mRNA和蛋白水平。 Neurotrophin-3（NT-3）mRNA和蛋白质的表达模式均显示出面积差异。在感觉和运动区域，出生后一周，NT-3 mRNA和蛋白质水平开始下降。相反，在新生皮层区域的第三次产后一周，该水平下降了。脑源性神经营养因子（BDNF）蛋白的水平在发育过程中以区域依赖性方式改变，而mRNA则没有。 BDNF蛋白水平的下降开始于感觉和运动新皮层区域，比联合新皮质区域更早，这表明就神经营养蛋白的发育变化而言，感觉和运动新皮层区域的发育比联合区域早。

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