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首页> 外文期刊>Experimental Brain Research >Impaired scaling of responses to vestibular stimulation in incomplete SCI.
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Impaired scaling of responses to vestibular stimulation in incomplete SCI.

机译:不完整SCI中对前庭刺激反应的缩放比例受损。

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摘要

Patients with incomplete spinal cord injury (iSCI) have impaired postural control leading to a high danger of falling. Clinically, it is impossible to assess the extent to which postural instability due to sensorimotor deficit is influenced by a disturbance in the vestibulospinal pathways. Galvanic vestibular stimulation (GVS) was applied to investigate changes in the vestibular spinal responses and their potential influence on postural stability in iSCI patients. Six chronic iSCI patients and age-matched controls were stimulated with a bipolar binaural stimulus. The centre of pressure (CoP) and soleus EMG responses during free standing with closed eyes on firm and compliant ground were measured. The impairment in postural stability was assessed by the mean amplitude of CoP deflections during two minutes undisturbed standing. Although iSCI patients were significantly less stable than controls, direct GVS responses of the soleus EMG and postural sways tended to be increased on firm ground. The GVS responses increased when changing from firm to compliant ground, showing a close correlation between the extent of postural instability and the response amplitudes. Therefore, challenging proprioceptive feedback induced a significant up-modulation of the GVS responses. However, when we took the postural instability in iSCI patients into account, the EMG and CoP responses to GVS were reduced compared to controls. The combined assessment of EMG and CoP responses to GVS complements the clinical examination and permits evaluation of the preservation and modulation of vestibulospinal responses in iSCI.
机译:脊髓损伤不完全(iSCI)的患者姿势控制受损,导致高度跌倒的危险。在临床上,不可能评估由于感觉运动缺陷引起的姿势不稳定性受前庭脊髓通道干扰的影响程度。电流前庭刺激(GVS)用于研究iSCI患者前庭脊柱反应的变化及其对姿势稳定性的潜在影响。双极双耳刺激刺激了六位慢性iSCI患者和年龄匹配的对照组。测量了在牢固站立的地面上闭着眼睛站立时的压力中心(CoP)和比目鱼肌电图反应。姿势稳定性的损害是通过两分钟不受干扰站立时CoP偏斜的平均幅度来评估的。尽管iSCI患者的稳定性远不如对照组,但比目鱼肌的直接GVS反应和体位摇摆在稳固的基础上趋于增加。当从坚固地面变为顺应地面时,GVS响应增加,表明姿势不稳的程度与响应幅度之间密切相关。因此,具有挑战性的本体感受反馈诱导了GVS反应的显着上调。但是,当我们考虑iSCI患者的姿势不稳定性时,与对照组相比,对GVS的EMG和CoP反应降低了。对GVS的EMG和CoP反应的综合评估补充了临床检查,并可以评估iSCI中前庭脊髓反应的保存和调节。

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