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首页> 外文期刊>Experimental Brain Research >The effects of vitamin E on penicillin-induced epileptiform activity in rats.
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The effects of vitamin E on penicillin-induced epileptiform activity in rats.

机译：维生素E对大鼠青霉素诱导的癫痫样活性的影响。

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摘要

Epilepsy is a disorder characterized by recurrent seizures, which can increase the content of reactive oxygen in the brain. Active oxygen free radical scavengers such as ascorbic acid or alpha-tocopherol (vitamin E) might prevent epilepsy. A variety of animal seizure models exist which help to document the effects of vitamin E and specify its action. In this study, we have evaluated dose-dependent effect of alpha-tocopherol on penicillin-induced epileptiform activity, analyzed by electrocorticogram (ECoG). The epileptiform activity was induced by microinjection of penicillin into the left sensorimotor cortex. Thirty minutes after penicillin injection, 100, 300, or 500 mg/kg of alpha-tocopherol was administrated intramuscularly (i.m.). alpha-Tocopherol (100, 300, or 500 mg/kg) alone did not significantly change the spike amplitudes in non-penicillin pretreated control animals. alpha-Tocopherol of 300, or 500 mg/kg significantly decreased the frequency of epileptiform activity in the penicillin-pretreated animals. The low dose of alpha-tocopherol (100 mg/kg) did not significantly change either amplitude or frequency of epileptiform activity. alpha-Tocopherol of 500 mg/kg i.m. was the most effective dose in changing of frequency on penicillin-induced epileptiform activity. The anti-convulsant effects of alpha-tocopherol appeared 80, 60, 30 min after alpha-tocopherol injection in 300, 500, and 3 day vitamin E supplemented groups. These data indicate that alpha-tocopherol decreases the frequency of penicillin-induced epileptic activity.
机译：癫痫病是一种反复发作的疾病，可增加大脑中活性氧的含量。活性氧自由基清除剂，例如抗坏血酸或α-生育酚（维生素E）可能会预防癫痫病。存在多种动物癫痫发作模型，这些模型有助于记录维生素E的作用并明确其作用。在这项研究中，我们评估了α-生育酚对青霉素诱导的癫痫样活性的剂量依赖性作用，并通过脑电图（ECoG）进行了分析。癫痫样活动是通过向左感觉运动皮层微注射青霉素诱导的。青霉素注射后30分钟，肌肉内（i.m.）注射100、300或500 mg / kg的α-生育酚。单独使用α-生育酚（100、300或500 mg / kg）不会显着改变未经青霉素预处理的对照动物的峰值幅度。 300或500 mg / kg的α-生育酚可显着降低青霉素预处理动物的癫痫样活动频率。低剂量的α-生育酚（100 mg / kg）没有明显改变癫痫样活动的幅度或频率。 i.m. 500 mg / kg的α-生育酚在改变频率上最有效的剂量是青霉素诱导的癫痫样活动。在300、500和3天补充维生素E的组中，注射α-生育酚后80、60、30分钟出现α-生育酚的抗惊厥作用。这些数据表明α-生育酚降低了青霉素诱导的癫痫活性的频率。

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