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首页> 外文期刊>Experimental dermatology >Human primary dendritic cell subsets differ in their IL-12 release in response to Leishmania major infection.
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Human primary dendritic cell subsets differ in their IL-12 release in response to Leishmania major infection.

机译：人类原代树突状细胞亚群在响应利什曼原虫感染后的IL-12释放量不同。

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Immunity against leishmaniasis has primarily been studied in experimental infections of mice. It was shown that infected skin dendritic cells (DC) are critical for the induction of protection against this pathogen, and targeting skin DC in vaccination approaches in mice has proven to be successful. However, little is known about the contribution of human DC subsets from the skin to primary immunity against this pathogen. In this study, we have analysed the interaction between different human DC subsets and Leishmania major. Primary human myeloid and monocyte-derived DC ingested the parasite comparable to that of murine skin DC, and this resulted in DC activation and IL-12 release, a cytokine essential for the induction of Th1/Tc1-dependent protection. Interestingly, both Langerhans cells and plasmacytoid DC did not appear to contribute to protection in humans. Thus, in leishmaniasis, both murine and human data suggest that dermal inflammatory DC appear to be superior in promoting protection.
机译：主要在小鼠实验性感染中研究了抗利什曼病的免疫力。结果表明，感染的皮肤树突状细胞（DC）对于诱导针对这种病原体的保护至关重要，并且已证明在小鼠的疫苗接种方法中靶向皮肤DC是成功的。但是，关于皮肤中人类DC亚群对这种病原体的初级免疫的贡献知之甚少。在这项研究中，我们分析了不同的人类DC子集和利什曼原虫的相互作用。原发性人类髓样和单核细胞衍生的DC摄入的寄生虫与鼠类皮肤DC相当，这导致DC激活和IL-12释放，这是诱导Th1 / Tc1依赖性保护所必需的细胞因子。有趣的是，朗格汉斯细胞和浆细胞样DC似乎都没有对人类的保护做出贡献。因此，在利什曼病中，鼠和人的数据均表明，皮肤炎性DC似乎在促进保护方面是优越的。

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