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首页> 外文期刊>Experimental and clinical endocrinology and diabetes: Official journal, German Society of Endocrinology [and] German Diabetes Association >Total testosterone and sex hormone-binding globulin are significantly associated with metabolic syndrome in middle-aged and elderly men
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Total testosterone and sex hormone-binding globulin are significantly associated with metabolic syndrome in middle-aged and elderly men

机译：总睾酮和性激素结合球蛋白与中老年男性代谢综合征显着相关

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摘要

Testosterone and sex hormone-binding globulin (SHBG) have been shown to be associated with metabolic syndrome (MS) in men. This study aimed at validating these relationships in a group of middle-aged and elderly men and assessing their strength of association to MS. A cross-sectional study of 332 Malaysian men aged 40 years and above was conducted. The blood of subject was collected under fasting condition for determination of testosterone, SHBG, glucose and lipid levels. Their medical history, smoking and alcohol consumption status, waist circumference (WC), body mass index (BMI) and blood pressure (BP) were recorded. All testosterone and SHBG levels were significantly reduced in MS subjects compared to non-MS subjects (p<0.05). Testosterone and SHBG were correlated significantly with most of the MS indicators without adjustments. In multiple regression analysis, the triglyceride level was the only MS indicator that was significantly, inversely and independently associated with all testosterone measurements and SHBG (p<0.05). Waist circumference was significantly and negatively associated with SHBG level (p<0.05) though not independent of BMI. Total testosterone and SHBG were significantly and inversely associated with the presence of MS. Testosterone and SHBG are potential intervention targets for the prevention of MS in men.
机译：睾丸激素和性激素结合球蛋白（SHBG）已被证明与男性代谢综合征（MS）有关。这项研究旨在验证一组中老年男性的这些关系，并评估其与MS的关联强度。进行了332名40岁及以上的马来西亚男性的横断面研究。在禁食条件下收集受试者的血液以测定睾丸激素，SHBG，葡萄糖和脂质水平。记录他们的病史，吸烟和饮酒状况，腰围（WC），体重指数（BMI）和血压（BP）。与非MS受试者相比，MS受试者的所有睾丸激素和SHBG水平均显着降低（p <0.05）。无需调整，睾丸激素和SHBG与大多数MS指标显着相关。在多元回归分析中，甘油三酸酯水平是唯一与所有睾丸激素测量值和SHBG显着，相反和独立相关的MS指标（p <0.05）。腰围与SHBG水平显着负相关（p <0.05），尽管与BMI无关。总睾丸激素和SHBG与MS的存在呈显着负相关。睾丸激素和SHBG是预防男性MS的潜在干预目标。

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