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Advances in the diagnosis of anorexia nervosa and bulimia nervosa using brain imaging

机译:脑成像诊断神经性厌食症和神经性贪食症的研究进展

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Introduction: Anorexia nervosa (AN) and bulimia nervosa (BN) are severe psychiatric disorders and the availability of brain imaging techniques hold promise that those techniques will be useful in clinical practice. Areas covered: In this review, the author describes currently available brain imaging techniques and focus on the brain imaging methods: functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). These techniques have helped describe alterations in brain circuitry in AN and BN that related to anxiety and reward processing. Novel computational models help further define brain function in relation to particular neurotransmitters. Expert opinion: Brain imaging techniques are exciting methods to learn about brain function, and progress has been made to identify in healthy populations brain circuits that code behaviors. These techniques have been used in AN and BN over the past decade and have improved our understanding of brain function in those disorders. Still, human brain imaging is not at a point yet where it could be used diagnostically. However, with the refinement of imaging hardware as well as improved models that describe brain function we will get closer to our aims not only to better understand the neurobiology of those disorders, but also to predict illness development, treatment response and long-term prognosis.
机译:简介:神经性厌食症(AN)和神经性贪食症(BN)是严重的精神疾病,并且大脑成像技术的可用性有望使这些技术在临床实践中有用。涵盖的领域:在这篇综述中,作者描述了当前可用的大脑成像技术,并着重介绍了大脑成像方法:功能磁共振成像(fMRI)和正电子发射断层扫描(PET)。这些技术已帮助描述了与焦虑和奖赏处理有关的AN和BN大脑回路的变化。新颖的计算模型有助于进一步定义与特定神经递质有关的脑功能。专家意见:大脑成像技术是了解大脑功能的令人兴奋的方法,并且已经在识别健康人群中编码行为的大脑回路方面取得了进展。在过去的十年中,这些技术已在AN和BN中使用,并增进了我们对这些疾病中脑功能的理解。尽管如此,人脑成像还没有被用于诊断。但是,随着成像硬件的改进以及描述脑功能的模型的改进,我们不仅将更接近于我们的目标,不仅可以更好地了解这些疾病的神经生物学,而且可以预测疾病的发展,治疗反应和长期预后。

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