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首页> 外文期刊>Expert opinion on medical diagnostics. >Role of molecular diagnostics in the management of viral hepatitis B
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Role of molecular diagnostics in the management of viral hepatitis B

机译：分子诊断在乙型病毒性肝炎管理中的作用

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Despite the availability of a safe and effective vaccine, chronic hepatitis B virus (HBV) infection continues to be a global health concern with an estimated 350 - 400 million people infected worldwide. Globally, HBV is the leading cause of chronic liver disease that may progress to cirrhosis and hepatocellular carcinoma. Therefore, accurate diagnosis and classification of the disease are important to determine whether therapy is needed. Areas covered: The review contains an overview of recent data on the existing and emerging developments in the molecular diagnostic and monitoring tools for chronic liver disease. Expert opinion: Monitoring of HBV viral load is the most widely used method in assessing liver disease severity, predicting development of cirrhosis and hepatocellular carcinoma, deciding initiation of antiviral therapy, assessing treatment response as well as early detection of emergence of drug resistance. Some recent studies have downplayed the importance of viral load in HBV management. Phenotyping/genotyping methods can establish emergent resistance to antivirals. Increasing number of reports suggest that clinical outcome and efficacy of antiviral treatment might vary with HBV genotype and precore/core promoter mutants. The importance of covalently closed circular DNA is also becoming apparent in this regard. Further studies on the development of newer molecular methods for a better management of chronic hepatitis B (CHB) will minimize morbidity in CHB.
机译：尽管可获得安全有效的疫苗，慢性乙型肝炎病毒（HBV）感染仍然是全球健康问题，全世界估计有350至4亿人感染。在全球范围内，HBV是可能会发展为肝硬化和肝细胞癌的慢性肝病的主要原因。因此，疾病的准确诊断和分类对于确定是否需要治疗很重要。涵盖领域：综述概述了有关慢性肝病分子诊断和监测工具的现有和新兴发展的最新数据。专家意见：监测乙肝病毒载量是评估肝病严重程度，预测肝硬化和肝细胞癌发展，决定开始抗病毒治疗，评估治疗反应以及及早发现耐药性的最广泛使用的方法。最近的一些研究淡化了病毒载量在HBV管理中的重要性。表型/基因分型方法可以建立对抗病毒药的紧急耐药性。越来越多的报告表明，抗病毒治疗的临床结果和疗效可能随HBV基因型和前核心/核心启动子突变而变化。在这方面，共价闭合的环状DNA的重要性也变得显而易见。进一步研究开发新的分子方法以更好地控制慢性乙型肝炎（CHB）可使CHB的发病率降至最低。

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