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首页> 外文期刊>Expert opinion on pharmacotherapy >Developments in the pharmacotherapeutic management of spontaneous preterm labor.
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Developments in the pharmacotherapeutic management of spontaneous preterm labor.

机译：自发性早产的药物治疗管理方面的发展。

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摘要

BACKGROUND: Preterm birth is the major cause of perinatal mortality and morbidity in the developed world. OBJECTIVE: The aim of this study was to establish the importance of preterm birth and the huge healthcare costs involved and review the pathophysiology of preterm labor and the use of antepartum glucocorticoids, which are the main reason why tocolytics are used to prevent or delay preterm birth. The study also reviewed the range of tocolytics available, their mode of action and the evidence for their efficacy and fetomaternal safety. METHODS: An extensive review of the literature using well-recognized and accepted scientific search engines was employed. RESULTS/CONCLUSIONS: The perfect tocolytic does not exist. The evidence to support the use of magnesium sulfate as a tocolytic is poor. The use of beta-agonists is decreasing worldwide as clinicians move to nifedipine or atosiban, which are as effective but much safer. Although nifedipine is cheaper than atosiban and can be administered orally, the evidence to support atosiban is much superior to that of nifedipine and there have been recent safety concerns over nifedipine.
机译：背景：早产是发达国家围生儿死亡率和发病率的主要原因。目的：本研究的目的是确定早产的重要性和所涉及的巨额医疗费用，并回顾早产的病理生理学和使用产前糖皮质激素，这是使用溶栓剂预防或延迟早产的主要原因。这项研究还回顾了可使用的生育抑制剂的范围，作用方式以及其功效和母体安全性的证据。方法：使用公认的和公认的科学搜索引擎对文献进行广泛的审查。结果/结论：不存在完美的宫缩抑制剂。支持使用硫酸镁作为宫缩抑制剂的证据很差。随着临床医生转向硝苯地平或阿托西班，β-激动剂的使用在全球范围内正在减少，硝苯地平或阿托西班虽然有效，但更安全。尽管硝苯地平比阿托西班便宜并且可以口服给药，但支持阿托西班的证据远远优于硝苯地平，并且最近对硝苯地平存在安全性担忧。

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