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首页> 外文期刊>Expert opinion on pharmacotherapy >Combination therapy with naltrexone and bupropion for obesity.
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Combination therapy with naltrexone and bupropion for obesity.

机译：纳曲酮和安非他酮联合治疗肥胖症。

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INTRODUCTION: Although pharmacological treatments for obesity represent only one option in managing obesity, they are a useful tool in an otherwise extremely limited armamentarium. Naltrexone/bupropion combination therapy was developed by using technological advances that have improved our understanding of how the brain regulates body weight. AREAS COVERED: This review covers the development of naltrexone/bupropion combination therapy for obesity, as well as the published clinical trials on the safety and efficacy of the combination in overweight and obese humans. The effect of naltrexone/bupropion on food craving seems to be unique, and the implications of this finding for weight loss are discussed. EXPERT OPINION: Safety and tolerability issues seem to be manageable and consistent with the documented effects of each component. Appropriate patient management should address the mild sympathomimetic effect of bupropion, although the FDA has required that a cardiovascular outcomes study be conducted preapproval to determine the effects of long-term use of naltrexone/bupropion in an overweight/obese population. When used in conjunction with diet and exercise, the naltrexone/bupropion combination may be a useful treatment option for obesity, especially for overweight and obese adults who report difficulty controlling eating behavior and their response to food cravings.
机译：简介：尽管肥胖的药物治疗仅是控制肥胖的一种选择，但它们在原本极其有限的军备库中是一种有用的工具。纳曲酮/安非他酮联合疗法是通过利用技术进步开发的，该技术进步使我们对大脑如何调节体重的理解有所提高。覆盖的领域：这篇综述涵盖了纳曲酮/安非他酮联合治疗肥胖症的开发，以及已发表的有关该组合在超重和肥胖人群中的安全性和有效性的临床试验。纳曲酮/安非他酮对食物的渴望似乎是独特的，并且讨论了该发现对减肥的影响。专家意见：安全性和可容忍性问题似乎是可管理的，并且与每个组件记录在案的效果一致。适当的患者管理应解决安非他酮的轻度拟交感神经作用，尽管FDA要求在批准前进行心血管结局研究，以确定长期使用纳曲酮/安非他酮对超重/肥胖人群的影响。当与饮食和运动结合使用时，纳曲酮/安非他酮的组合可能是肥胖的有用治疗选择，尤其是对于那些难以控制饮食行为及其对食物渴望的反应的超重和肥胖成年人。

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