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首页> 外文期刊>Expert opinion on pharmacotherapy >Treatment of chlamydial infections.
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Treatment of chlamydial infections.

机译：衣原体感染的治疗。

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INTRODUCTION: Chlamydiae are obligate intracellular bacterial pathogens whose entry into mucosal epithelial cells is required for intracellular survival and subsequent growth. The life cycle of Chlamydia spp. and the ability to cause persistent, often subclinical infection, has major ramifications for diagnosis and treatment of C. trachomatis and C. pneumoniae infections in humans. AREAS COVERED: This up-to-date review describes the current state of knowledge of antimicrobial susceptibilities and treatment of genital infections due to C. trachomatis and respiratory infections due to C. pneumoniae. EXPERT OPINION: Chlamydiae are susceptible to antibiotics that interfere with DNA and protein synthesis, including tetracyclines, macrolides and quinolones, which are the compounds that have been most extensively studied and used for treatment of human infection. Treatment of individuals with C. trachomatis genital infection prevents sexual transmission and complications, including pelvic inflammatory disease. Treatment of pregnant women will prevent the transmission of infection to infants during delivery. The benefits of treatment of respiratory infections due to C. pneumoniae are more difficult to assess, primarily because of the lack of FDA-approved, specific diagnostic tests for detection of the organism in clinical samples. The majority of published studies have relied on serology for diagnosis, making it difficult to assess microbiologic efficacy.
机译：简介：衣原体是专性细胞内细菌病原体，其进入粘膜上皮细胞是细胞内存活和随后生长所必需的。衣原体的生命周期。以及引起持续的，经常是亚临床感染的能力，对诊断和治疗人类沙眼衣原体和肺炎衣原体感染具有重要意义。覆盖的区域：本最新审查介绍了抗菌素敏感性和沙眼衣原体引起的生殖器感染以及肺炎衣原体引起的呼吸道感染的治疗的当前知识状态。专家意见：衣原体对干扰DNA和蛋白质合成的抗生素敏感，包括四环素，大环内酯类和喹诺酮类，这是已被广泛研究并用于治疗人类感染的化合物。沙眼衣原体生殖器感染个体的治疗可防止性传播和并发症，包括盆腔炎。孕妇的治疗将防止分娩期间传染给婴儿。由于肺炎衣原体引起的呼吸道感染的治疗效果更难评估，这主要是因为缺乏FDA批准的用于检测临床样品中生物的特异性诊断测试。大多数已发表的研究依靠血清学进行诊断，因此很难评估微生物学功效。

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