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Antituberculosis therapy for 2012 and beyond.

机译：2012年及以后的抗结核治疗。

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INTRODUCTION: In terms of human suffering, tuberculosis has a huge impact on global society, making it arguably the most important infectious disease in history. Despite the devastating impact on society, the tools to fight tuberculosis are very limited. Current standard therapy has been used for over 40 years and threats, such as the HIV epidemic and drug-resistant strains, undermine efforts to control the disease. New drugs are needed to address the challenges faced globally. AREAS COVERED: Current therapy is briefly reviewed in this paper and then new doses and combinations of existing drugs are presented. New candidate drugs are also discussed, along with the potential benefits and pitfalls of each of the compounds and approaches to therapy. EXPERT OPINION: Despite the need to develop new drugs, the ability of programs to deliver existing therapies must not be neglected. Directly observed therapy and a standard basic level of care for all patients with tuberculosis, regardless of where they reside, is imperative, and will ensure that new drugs and regimens will have the greatest possible impact. New combination regimens, including PA 824 and TMC207, in combination with existing drugs, are very exciting - not only because of their ability to shorten treatment regimens in pan-susceptible cases, but also because they can be used among drug-resistant strains. Although an effective vaccine will probably be necessary to eliminate tuberculosis, new drugs and combination regimens have the potential to save millions of lives before tuberculosis is finally eliminated.
机译：简介：就人类的痛苦而言，结核病对全球社会产生了巨大影响，可以说是历史上最重要的传染病。尽管对社会造成了毁灭性的打击，但抗击结核病的工具却非常有限。当前的标准疗法已经使用了40多年，诸如HIV流行和耐药株等威胁破坏了控制该疾病的努力。需要新药来应对全球面临的挑战。覆盖的领域：本文简要回顾了当前的治疗方法，然后介绍了新剂量和现有药物的组合。还讨论了新的候选药物，以及每种化合物的潜在益处和陷阱以及治疗方法。专家意见：尽管需要开发新药，但不得忽视提供现有疗法的计划能力。对于所有结核病患者，无论他们身在何处，都必须采取直接观察的治疗方法和标准的基本护理水平，这必不可少，并将确保新药和新疗法产生最大的影响。包括PA 824和TMC207在内的新组合疗法与现有药物的结合非常令人兴奋-不仅是因为它们有能力缩短易感病例的治疗方案的能力，而且还因为它们可以在耐药菌株中使用。尽管可能必须有一种有效的疫苗来消除结核病，但在最终消除结核病之前，新药和联合疗法有可能挽救数百万人的生命。

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