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首页> 外文期刊>Experimental Eye Research >Short-term effects of extremely low-frequency pulsed electromagnetic field and pulsed low-level laser therapy on rabbit model of corneal alkali burn
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Short-term effects of extremely low-frequency pulsed electromagnetic field and pulsed low-level laser therapy on rabbit model of corneal alkali burn

机译：极低频脉冲电磁场​​和脉冲低水平激光治疗对兔角膜碱烧伤模型的短期影响

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This study was conducted to investigate the effect of combining extremely low frequency pulsed electromagnetic field (ELF-PEMF) and low-level laser therapy (LLLT) on alkali-burned rabbit corneas. Fifty alkali-burned corneas of 50 rabbits were categorized into five groups: ELF-PEMF therapy with 2 mT intensity (ELF 2) for 2 h daily; LLLT for 30 min twice daily; combined ELF-PEMF and LLLT (ELF + LLLT); medical therapy (MT); and control (i.e., no treatment). Clinical examination and digital photography of the corneas were performed on days 0, 2, 7, and 14. After euthanizing the rabbits, the affected eyes were evaluated by histopathology. The clinical and histopathologic results were compared between the groups. On days 7 and 14, no significant difference in the corneal defect area was evident between the ELF, LLLT, ELF + LLLT, and MT groups. Excluding the controls, none of the study groups demonstrated a significant corneal neovascularization in both routine histopathology and immunohistochemistry for CD31. Keratocyte loss was significantly higher in the MT group than in the ELF, LLLT, and ELF + LLLT groups. Moderate to severe stromal inflammation in the LLLT group was comparable with that in the MT group and was significantly lower than that in the other groups. In conclusion, combining LLLT and ELF was not superior to ELF alone or LLLT alone in healing corneal alkali burns. However, given the lower intensity of corneal inflammation and the lower rate of keratocytes loss with LLLT, this treatment may be superior to other proposed treatment modalities for healing alkali-burned corneas. (C) 2016 Elsevier Ltd. All rights reserved.
机译：进行这项研究以研究结合极低频脉冲电磁场​​（ELF-PEMF）和低水平激光疗法（LLLT）对碱烧兔角膜的影响。将50只兔的碱烧伤角膜分为五组：每天2 h强度为2 mT（ELF 2）的ELF-PEMF治疗;每天2 h进行ELF-PEMF治疗。每天两次LLLT 30分钟; ELF-PEMF和LLLT（ELF + LLLT）组合;药物治疗（MT）;和控制（即不进行治疗）。在第0、2、7和14天进行角膜的临床检查和数字摄影。对兔子实施安乐死后，通过组织病理学对患眼进行评估。比较两组之间的临床和组织病理学结果。在第7天和第14天，ELF，LLLT，ELF + LLLT和MT组之间的角膜缺损区域无明显差异。除对照组外，所有研究组均未在CD31的常规组织病理学和免疫组化中显示出明显的角膜新生血管形成。 MT组的角膜细胞损失明显高于ELF，LLLT和ELF + LLLT组。 LLLT组的中度至重度基质炎症与MT组相当，并且显着低于其他组。总之，在治愈角膜碱烧伤中，LLLT和ELF的结合并不优于单独使用ELF或单独使用LLLT。但是，考虑到用LLLT降低角膜炎症的强度和降低角膜细胞的速率，这种治疗可能优于其他建议的碱烧伤角膜治疗方法。 （C）2016 Elsevier Ltd.保留所有权利。

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