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首页> 外文期刊>Experimental Gerontology >Changes of MMP-1 and collagen type Ialpha1 by UVA, UVB and IRA are differentially regulated by Trx-1.
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Changes of MMP-1 and collagen type Ialpha1 by UVA, UVB and IRA are differentially regulated by Trx-1.

机译：Trx-1分别调节UVA，UVB和IRA对MMP-1和Ialpha1型胶原蛋白的影响。

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摘要

Exposure of human skin to solar radiation, which includes ultraviolet (UV) radiation (UVA and UVB) visible light and infrared radiation, induces skin aging. The effects of light have been attributed to irradiation-induced reactive oxygen species (ROS) formation, but the specific signaling pathways are not well understood. Detrimental effects of solar radiation are dermal diseases and photoaging. Exposure of cultured human dermal fibroblasts to UVA, UVB or IRA increased ROS formation in vitro. One important redox regulator is the oxidoreductase thioredoxin-1 (Trx). Trx is ubiquitously expressed and has anti-oxidative and anti-apoptotic properties. Besides its function to reduce H(2)O(2), Trx binds to and regulates transcription factors. The aim of this study was to investigate whether Trx influences the regulation of MMP-1 and collagen Ialpha1 by UVA, UVB and IRA. We irradiated human dermal fibroblasts with UVA, UVB and IRA. UVA, UVB and IRA upregulated MMP-1 expression. Trx inhibited UVA-induced MMP-1 upregulation in a NFkappaB dependent manner. UVA, UVB and IRA reduced collagen Ialpha1 expression. Incubation with Trx inhibited the effects of UVB and IRA on collagen Ialpha1 expression. In conclusion, MMP-1 and collagen Ialpha1, which play important roles in aging processes, seems to be regulated by different transcriptional mechanisms and Trx can only influence distinct signaling pathways induced by UVA, UVB and probably IRA. Thus, Trx may serve as an important contributor to an "anti-aging therapeutic cocktail".
机译：人体皮肤暴露于太阳辐射（包括紫外线（UVA和UVB）可见光和红外辐射）会导致皮肤老化。光的影响已归因于辐射诱导的活性氧（ROS）的形成，但具体的信号传导途径尚不十分清楚。太阳辐射的有害影响是皮肤疾病和光老化。将培养的人真皮成纤维细胞暴露于UVA，UVB或IRA会增加体外的ROS形成。一种重要的氧化还原调节剂是氧化还原酶硫氧还蛋白-1（Trx）。 Trx被普遍表达，并具有抗氧化和抗凋亡特性。 Trx除了具有减少H（2）O（2）的功能外，还可以结合并调节转录因子。这项研究的目的是调查Trx是否会影响UVA，UVB和IRA对MMP-1和胶原Ialpha1的调节。我们用UVA，UVB和IRA照射了人类皮肤成纤维细胞。 UVA，UVB和IRA上调MMP-1表达。 Trx以NFkappB依赖性方式抑制UVA诱导的MMP-1上调。 UVA，UVB和IRA降低了胶原Ialpha1的表达。 Trx孵育可抑制UVB和IRA对胶原Ialpha1表达的影响。总之，在衰老过程中起重要作用的MMP-1和胶原蛋白Ialpha1似乎受到不同转录机制的调控，Trx只能影响UVA，UVB和IRA诱导的不同信号通路。因此，Trx可能是“抗衰老治疗鸡尾酒”的重要贡献者。

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