Regulation of the Na(+)/H(+) exchanger in the healthy and diseased myocardium.

Fliegel L

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Regulation of the Na(+)/H(+) exchanger in the healthy and diseased myocardium.

机译：在健康和患病心肌中Na（+）/ H（+）交换子的调节。

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BACKGROUND: Na(+)/H(+) exchangers (NHE's) are membrane proteins that regulate ion fluxes, they extrude one intracellular proton in exchange for one extracellular sodium thereby regulating intracellular pH. Mammalian NHE's have nine isoforms, NHE1-NHE9. NHE1 is present in all mammalian cell and is the only isoform present in cardiomyocytes. NHE1 contributes to damage to the myocardium with ischemia and reperfusion and to heart hypertrophy. OBJECTIVE: To summarize the current state of knowledge with regard to regulation of NHE1 in the myocardium. METHODS: A review of relevant literature. RESULTS: Inhibition of NHE reduces ischemia-reperfusion damage and development of hypertrophy. Extracellular-signal-regulated kinase (ERK)-dependent phosphorylation activates NHE1 in the myocardium. Ischemia and subsequent reperfusion activates the ERK-dependent pathway and may lead to aggravation of damage. CONCLUSIONS: Elucidation of the regulatory pathway of NHE1 in the myocardium could lead to novel approaches to reduce heart hypertrophy and ischemia-reperfusion damage.

机译：背景：Na（+）/ H（+）交换剂（NHE's）是调节离子通量的膜蛋白，它们挤出一个细胞内质子来交换一种细胞外钠，从而调节细胞内pH。哺乳动物NHE具有9个亚型，即NHE1-NHE9。 NHE1存在于所有哺乳动物细胞中，并且是心肌细胞中存在的唯一同工型。 NHE1有助于缺血和再灌注对心肌的损害以及心脏肥大。目的：总结关于NHE1在心肌中调节的知识的现状。方法：相关文献综述。结果：抑制NHE可减少缺血再灌注损伤和肥大的发展。细胞外信号调节激酶（ERK）依赖性磷酸化激活心肌中的NHE1。缺血和随后的再灌注激活了ERK依赖性途径，并可能导致损害加重。结论：阐明心肌中NHE1的调节途径可能导致减少心脏肥大和缺血再灌注损伤的新方法。

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《Expert opinion on therapeutic targets》 |2009年第1期|共14页
作者
Fliegel L;
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正文语种 eng
中图分类药学;
关键词
Myocardium; Physiological reperfusion; Ischemia; 心肌; 局部缺血;

机译：Myocardium;Physiological reperfusion;Ischemia;心肌;局部缺血;

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1. Regulation of the Na(+)/H(+) exchanger in the healthy and diseased myocardium. [J] . Fliegel L Expert opinion on therapeutic targets . 2009,第1期

机译：在健康和患病心肌中Na（+）/ H（+）交换子的调节。
2. Overexpression of the Na+/H+ exchanger and ischemia-reperfusion injury in the myocardium. [J] . Imahashi K, Mraiche F, Steenbergen C, American Journal of Physiology . 2007,第5期

机译：Na + / H +交换子的过表达和心肌缺血再灌注损伤。
3. Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium. [J] . Hileeto D, Cukiernik M, Mukherjee S, Diabetes/metabolism research and reviews . 2002,第5期

机译：糖尿病心肌中内皮素1和氢交换钠1的贡献。
4. Using hyperspectral reflectance data for discrimination between healthy and diseased plants, and determination of damage-level in diseased plants [C] . Hamed Hamid Muhammed Applied Imagery Pattern Recognition Workshop . 2002

机译：利用高光谱反射数据进行健康和患病植物之间的歧视，以及患病植物中的损伤水平
5. Nitric oxide and S-nitrosoglutathione exchange dynamics in healthy and diseased human airways. [D] . Shin, Hye-Won. 2001

机译：一氧化氮和S-亚硝基谷胱甘肽在健康和患病的人类呼吸道中交换动力学。
6. Sodium/calcium exchange modulates intracellular calcium overload during posthypoxic reoxygenation in mammalian working myocardium. Evidence from aequorin-loaded ferret ventricular muscles. [O] . Y Kihara, S Sasayama, M Inoko, 1994

机译：钠/钙交换调节哺乳动物工作心肌在低氧后再充氧过程中的细胞内钙超载。载有水母发光蛋白的雪貂心室肌的证据。
7. Recommendation for Council Regulation (EEC) concluding an Agreement in the form of an exchange of letters between the European Economic Community and the Republic of Algeria concerning the importation into the Community of fruit salads originating in Algeria; Recommendation for a Council Regulation (EEC) concluding an Agreement in the form of an exchange of letters between the European Economic Community and the Kingdom of Morocco concerning the importation into the Community of fruit salads originating in the Kingdom of Morocco; Recommendation for a Council Regulation (EEC) concluding an Agreement in the form of an exchange of letters between the European Economic Community and the Republic of Tunisia concerning the importation into the Community of fruit salads originating in Tunisia; Recommendation for Council Regulation (EEC) concluding an Agreement in the form of an exchange of letters betweenthe European Economic Community and the Republic of Algeria concerning the importation into the Community of bran and sharps originating in Algeria; Recommendation for Council Regulation (EEC) concluding an Agreement in the form of an exchange of letters between the European Economic Community and the Kingdom of Morocco concerning the importation into the Community of bran and sharpas originating in Morocco; Recommendation for Council Regulation (EEC) concluding an Agreement in the form of an exchange of letters betweenthe European Economic Community and the Republic of Tunisia concerning the importation into the Community of bran and sharps originating in Tunisia. COM (76) 176 final, 22 April 1976. [O] . 1976

机译：建议理事会条例（EEC）以欧洲经济共同体和阿尔及利亚共和国之间的换文形式签订协议，关于从阿尔及利亚进口的水果沙拉进口到共同体;建议理事会条例（EEC）以欧洲经济共同体与摩洛哥王国之间的换文形式缔结协定，内容涉及从摩洛哥王国进口水果沙拉进口共同体;建议理事会条例（EEC）以欧洲经济共同体和突尼斯共和国之间以源自突尼斯的水果沙拉进口共同体的信件交换形式达成协议;建议理事会条例（EEC）以交换信函的形式缔结协议欧洲经济共同体和阿尔及利亚共和国关于向阿尔及利亚进口糠和虾的进口共同体;建议理事会条例（EEC）以欧洲经济共同体与摩洛哥王国之间的换文形式签订协议，关于从原产于摩洛哥的麸皮和尖锐植物进口共同体;建议理事会条例（EEC）以交换信函的形式缔结协议欧洲经济共同体和突尼斯共和国关于从突尼斯进口麸皮和尖锐物进入共同体的问题。 COm（76）176决赛，1976年4月22日。

Regulation of the Na(+)/H(+) exchanger in the healthy and diseased myocardium.

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