Nephroprotective and clinical potential of statins in dialyzed patients.

Rysz J; Aronow WS; Stolarek R

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Nephroprotective and clinical potential of statins in dialyzed patients.

机译：他汀类药物在透析患者中的肾保护作用和临床潜力。

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BACKGROUND: The combination of increased cardiovascular mortality and vascular complications due to dyslipidaemia in chronic kidney disease (CKD) has focused attention onto the potential beneficial effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) inhibitors (statins) on the course of CKD. OBJECTIVE: To examine the use of statins in CKD. METHODS: A review of relevant literature. RESULTS/CONCLUSION: Current evidence from clinical trials in CKD patients on maintenance dialysis is limited. Therefore, the routine use of statins in this population remains the decision of individual physicians in discussion with their patients.

机译：背景：在慢性肾脏病（CKD）中，由于血脂异常而导致心血管疾病死亡率增加和血管并发症增加，已经将注意力集中在3-羟基-3-甲基戊二酰辅酶A还原酶（HMG-CoA）抑制剂（他汀类）的潜在有益作用上。在CKD的过程中。目的：研究他汀类药物在CKD中的使用。方法：相关文献综述。结果/结论：来自CKD患者维持性透析的临床试验的最新证据有限。因此，在这种人群中常规使用他汀类药物仍然是个别医师与患者讨论的决定。

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《Expert opinion on therapeutic targets》 |2009年第5期|共10页
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Rysz J; Aronow WS; Stolarek R;
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中图分类药学;
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1. Nephroprotective and clinical potential of statins in dialyzed patients. [J] . Rysz J, Aronow WS, Stolarek R Expert opinion on therapeutic targets . 2009,第5期

机译：他汀类药物在透析患者中的肾保护作用和临床潜力。
2. Needed: pragmatic clinical trials for statin-intolerant patients. [J] . Maningat P, Breslow JL The New England journal of medicine . 2011,第24期

机译：需要：针对他汀类药物不耐受患者的实用临床试验。
3. Clinical significance of mild lipid-lowering by statins for prevention of cardiovascular disease in Japanese high-risk patients. [J] . Miyazaki T, Daida H Circulation journal . 2010,第4期

机译：他汀类药物轻度降脂对预防日本高危患者心血管疾病的临床意义。
4. Characteristic Differences Between Water Dialyzed and Buffer Dialyzed Keratose Biomaterial [C] . Nils A. Potter, Mark Van Dyke Society for Biomaterials annual meeting and exposition . 2017

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5. Evaluation of a potential novel biomarker & derivation of clinical prediction rules for severe influenza in emergency department patients. [D] . Chen, Kuan-Fu. 2010

机译：对急诊科患者中严重流感的潜在新生物标志物的评估和临床预测规则的推导。
6. Current perspectives on statins as potential anti-cancer therapeutics: clinical outcomes and underlying molecular mechanisms [O] . Ali Fatehi Hassanabad 2019

机译：他汀类药物作为潜在抗癌药物的当前观点：临床结果和潜在的分子机制
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Nephroprotective and clinical potential of statins in dialyzed patients.

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