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首页> 外文期刊>Expert opinion on therapeutic targets >Could the Ebola virus matrix protein VP40 be a drug target?
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Could the Ebola virus matrix protein VP40 be a drug target?

机译：埃博拉病毒基质蛋白VP40是否可以成为药物靶标？

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摘要

Filoviruses are filamentous lipid-enveloped viruses and include Ebola (EBOV) and Marburg, which are morphologically identical but antigenically distinct. These viruses can be very deadly with outbreaks of EBOV having clinical fatality as high as 90%. In 2012 there were two separate Ebola outbreaks in the Democratic Republic of Congo and Uganda that resulted in 25 and 4 fatalities, respectively. The lack of preventive vaccines and FDA-approved therapeutics has struck fear that the EBOV could become a pandemic threat. The Ebola genome encodes only seven genes, which mediate the entry, replication, and egress of the virus from the host cell. The EBOV matrix protein is VP40, which is found localized under the lipid envelope of the virus where it bridges the viral lipid envelope and nucleocapsid. VP40 is effectively a peripheral protein that mediates the plasma membrane binding and budding of the virus prior to egress. A number of studies have demonstrated specific deletions or mutations of VP40 to abrogate viral egress but to date pharmacological inhibition of VP40 has not been demonstrated. This editorial highlights VP40, which is the most abundantly expressed protein of the virus and discusses VP40 as a potential therapeutic target.
机译：丝状病毒是丝状脂质包裹的病毒，包括埃博拉病毒（EBOV）和马尔堡病毒，它们在形态上是相同的，但在抗原上却是不同的。这些病毒在EBOV暴发时具有极高的致命性，其临床病死率高达90％。 2012年，刚果民主共和国和乌干达分别爆发了两次埃博拉疫情，分别造成25人和4人死亡。缺乏预防性疫苗和FDA批准的治疗剂使人们担心EBOV可能成为大流行的威胁。埃博拉病毒基因组仅编码七个基因，它们介导病毒从宿主细胞进入，复制和流出。 EBOV基质蛋白是VP40，它位于病毒的脂质包膜下，在该脂质桥上连接病毒脂质包膜和核衣壳。 VP40是有效的外周蛋白，可在病毒流出之前介导质膜结合和病毒出芽。大量研究表明，VP40的特定缺失或突变可消除病毒的排出，但迄今为止，尚未证明VP40的药理学抑制作用。这篇社论重点介绍了VP40，它是病毒中表达最丰富的蛋白质，并讨论了VP40作为潜在治疗靶标的问题。

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