Targeting CD73 and downstream adenosine receptor signaling in triple-negative breast cancer

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Targeting CD73 and downstream adenosine receptor signaling in triple-negative breast cancer

机译：靶向CD73和下游腺苷受体信号转导三阴性乳腺癌

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Introduction: Despite significant improvements in diagnosis and therapy over the past 20 years, breast cancer remains a worldwide public health issue. In particular, triple negative breast cancer (TNBC), a subset of very aggressive breast tumors, is associated with a poor prognosis and has very few efficient therapeutic options. The ectonucleotidase CD73 has recently emerged as a promising new target for TNBC in preclinical models. Pharmacological targeting of CD73 and downstream adenosine A2A/A2B receptor signaling is currently an active field of research that could lead to the development of new cancer therapeutics, including options against TNBC.Areas covered: This article reviews the basic structural and molecular features of CD73 and its role in the development of cancer, with a particular focus on CD73's role in the biology of TNBC.Expert opinion: It was recently demonstrated that CD73 expression in TNBC is associated with worse clinical outcomes and increased resistance to anthracycline chemotherapy. Targeted blockade of the CD73/A2A axis has been shown to impair various aspects of tumorigenesis and displays synergism with other anti-cancer treatments in preclinical studies. Hence, we strongly argue for the development of CD73 inhibitors and for the repositioning of A2A antagonists in cancer.

机译：简介：尽管过去20年来在诊断和治疗方面取得了显着进步，但乳腺癌仍然是世界范围内的公共卫生问题。尤其是，三阴性乳腺癌（TNBC）是侵略性极强的乳腺肿瘤的一部分，与预后不良相关，并且几乎没有有效的治疗选择。胞外核苷酸酶CD73最近在临床前模型中成为有希望的TNBC新靶标。 CD73和下游腺苷A2A / A2B受体信号转导的药理靶向目前是一个活跃的研究领域，可导致开发新的癌症治疗方法，包括针对TNBC的选择。涵盖的领域：本文概述了CD73和它在癌症发展中的作用，特别是CD73在TNBC生物学中的作用。专家意见：最近证明，TN73中CD73的表达与更差的临床结果和对蒽环类药物耐药性增加有关。在临床前研究中，已证明CD73 / A2A轴的靶向阻滞作用会削弱肿瘤发生的各个方面，并显示与其他抗癌治疗的协同作用。因此，我们强烈主张开发CD73抑制剂并重新定位癌症中的A2A拮抗剂。

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《Expert opinion on therapeutic targets》 |2014年第8期|共19页
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正文语种 eng
中图分类药学;
关键词
Adenosine receptors; CD73; Immunosuppression; Triple negative breast cancer;

机译：腺苷受体;CD73;免疫抑制;三阴性乳腺癌;

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1. Targeting CD73 and downstream adenosine receptor signaling in triple-negative breast cancer [J] . Expert opinion on therapeutic targets . 2014,第8期

机译：靶向CD73和下游腺苷受体信号转导三阴性乳腺癌
2. Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator [J] . Kuen-Haur Lee, En-Chi Hsu, Jih-Hwa Guh, The Journal of biological chemistry . 2011,第45期

机译：用新型腺苷一磷酸盐活化蛋白激酶（AMPK）活化剂在三重阴性乳腺癌中靶向能量代谢和致癌信号通路
3. hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression [J] . Michael G. Edwards, Katherine Vandervest, John Arcaroli, Biology Open . 2013,第7期

机译：hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中的抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶点）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用
4. Nanoparticles Coated with Frizzled7 Antibodies Enable Multivalent Binding for Enhanced Wnt Signaling Inhibition in Triple-Negative Breast Cancer [C] . Rachel S. Riley, Emily S. Day Society for Biomaterials annual meeting and exposition . 2018

机译：纳米颗粒涂有Frizzled7抗体使三价乳腺癌中增强Wnt信号抑制的多价结合。
5. Extracellular Vesicles: Isolation with Multivalent Aptamers and Conferring Receptors to Triple-Negative Breast Cancer Cells for Targeted Drug Delivery [D] . Xue, Fei. 2022

机译：细胞外囊泡：用多价适体分离，并赋予三阴性乳腺癌细胞的受体进行靶向药物递送
6. miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells [O] . Sonia G. Das, Mathilde Romagnoli, Nora D. Mineva, 2016

机译：miR-720是ADAM8诱导的ERK信号级联反应的下游靶标可促进三阴性乳腺癌细胞的迁移和侵袭性表型。
7. miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells [O] . 2016

机译：miR-720是ADAM8诱导的ERK信号级联反应的下游靶标，可促进三阴性乳腺癌细胞的迁移和侵袭性表型。

Targeting CD73 and downstream adenosine receptor signaling in triple-negative breast cancer

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