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首页> 外文期刊>Expert opinion on therapeutic targets >Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer.
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Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer.

机译：核因子-类胡萝卜素2相关因子2作为大肠癌的化学预防靶标。

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INTRODUCTION: Numerous epidemiological studies have linked consumption of cruciferous vegetables to a reduced risk of colorectal cancer (CRC) in individuals. It is currently well accepted that chronic inflammation is a contributing factor in 15 - 20% malignancies including CRC. Many chemopreventive compounds are effective in preclinical systems and many ongoing clinical trials are showing promising findings. Many of these compounds could activate the antioxidant responsive element (ARE), a critical regulatory element for Phase II protective/detoxification and antioxidative stress enzymes mediated by nuclear factor-erythroid 2-related factor 2 (Nrf2). Recently, Nrf2 has emerged as a novel target for the prevention of CRC. AREAS COVERED: A full literature search was performed using PubMed with the key words 'ARE, Nrf2, colon, colorectal cancer, chemoprevention, cancer prevention', and all relevant publications are included. EXPERT OPINION: The use of Nrf2 knockout mice has provided key insights into the toxicological and chemopreventive importance of this pathway. Mounting evidence has revealed that Nrf2 is a critical regulator of inflammation as well, a major driving force for CRC progression and formation. Targeting the Nrf2/ARE pathway may present a novel therapeutic approach for the treatment of not only colorectal inflammatory diseases but the frequent subsequent development of CRC as well.
机译：简介：许多流行病学研究已将食用十字花科蔬菜与降低个体患结直肠癌（CRC）的风险联系在一起。目前公认慢性炎症是包括CRC在内的15-20％恶性肿瘤的促成因素。许多化学预防化合物在临床前系统中有效，许多正在进行的临床试验显示出可喜的发现。这些化合物中的许多都可以激活抗氧化反应元件（ARE），这是II期保护/排毒和由核因子-类胡萝卜素2相关因子2（Nrf2）介导的抗氧化应激酶的关键调控元件。最近，Nrf2已成为预防CRC的新靶标。覆盖的区域：使用PubMed进行了全文检索，关键词为“ ARE，Nrf2，结肠，结肠直肠癌，化学预防，癌症预防”，所有相关出版物也包括在内。专家意见：Nrf2基因敲除小鼠的使用为该途径的毒理学和化学预防重要性提供了重要见解。越来越多的证据表明，Nrf2也是炎症的关键调节剂，也是CRC进展和形成的主要驱动力。靶向Nrf2 / ARE途径可能会提供一种新颖的治疗方法，不仅可以治疗结直肠炎，还可以治疗随后频繁发生的CRC。

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