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An oncogenic kinase: Putting PAK5 forward

机译：致癌激酶：将PAK5推向前进

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Introduction: Overexpression of p21-activated kinase 5 (PAK5) is discovered in many tumors, probably due to its regulation in cytoskeleton, antiapoptosis and proliferation. A better understanding of the modulation mechanisms of PAK5 is needed for the development of tumor treatment where current therapeutics is inadequate.Areas covered: This review discusses the current understanding of PAK5 functions as an oncogenic kinase in tumor cellular regulation. Mechanisms of action and molecular pathways involved in cytoskeleton regulation, antiapoptosis and proliferation of tumors are discussed.Expert opinion: PAKs are serine/threonine kinases and downstream effectors for Cdc42 and Rac, the subfamilies of Rho small GTPases. PAK5 shares sequence identities in p21-GTPase-binding domain and kinase domain and is completely different in other regions compared with other PAKs. Overexpression of PAK5 has been found in several tumors, probably due to its contribution to proliferation, cytoskeleton and anti-apoptosis. Additional regulation mechanisms which are independent of Rho GTPases also indicate that PAK5 functions as a special signal molecule in cellular signaling pathways of tumor progression.
机译：简介：在许多肿瘤中发现了p21活化激酶5（PAK5）的过表达，可能是由于其在细胞骨架，抗凋亡和增殖中的调控。在目前的治疗方法还不足的情况下，需要更好地了解PAK5的调控机制才能发展肿瘤治疗。涵盖的领域：本综述讨论了对PAK5在肿瘤细胞调节中作为致癌激酶起作用的最新认识。讨论了参与细胞骨架调节，抗凋亡和肿瘤增殖的作用机理和分子途径。专家意见：PAK是丝氨酸/苏氨酸激酶，是Rho小GTPases亚家族Cdc42和Rac的下游效应子。 PAK5在p21-GTPase结合结构域和激酶结构域中具有序列同一性，并且与其他PAK相比在其他区域完全不同。在多种肿瘤中发现了PAK5的过度表达，可能是由于其对增殖，细胞骨架和抗凋亡的影响。独立于Rho GTPases的其他调节机制还表明，PAK5在肿瘤进展的细胞信号通路中起特殊信号分子的作用。

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