Transglutaminase as a therapeutic target for celiac disease

Sulic Ana-Marija; Kurppa Kalle; Rauhavirta Tiina; Kaukinen Katri; Lindfors Katri

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Transglutaminase as a therapeutic target for celiac disease

机译：转谷氨酰胺酶作为乳糜泻的治疗靶标

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Introduction: The only current treatment for celiac disease is a strict gluten-free diet. The ubiquitous presence of gluten in groceries, however, makes the diet burdensome and difficult to maintain, and alternative treatment options are thus needed. Here, the important role of transglutaminase 2 (TG2) in the pathogenesis of celiac disease makes it an attractive target for drug development.

机译：简介：目前治疗腹腔疾病的唯一方法是严格的无麸质饮食。然而，在食品杂货中普遍存在麸质，这使饮食负担重且难以维持，因此需要替代治疗选择。在这里，转谷氨酰胺酶2（TG2）在腹腔疾病发病机理中的重要作用使其成为药物开发的有吸引力的目标。

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《Expert opinion on therapeutic targets》 |2015年第3期|共14页
作者
Sulic Ana-Marija; Kurppa Kalle; Rauhavirta Tiina; Kaukinen Katri; Lindfors Katri;
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正文语种 eng
中图分类药学;
关键词
celiac disease; drug; gluten; inhibitor; small-bowel; transglutaminase;

机译：乳糜泻;药物;面筋;抑制剂;小肠;转谷氨酰胺酶;

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1. Transglutaminase as a therapeutic target for celiac disease [J] . Sulic Ana-Marija, Kurppa Kalle, Rauhavirta Tiina, Expert opinion on therapeutic targets . 2015,第3期

机译：转谷氨酰胺酶作为乳糜泻的治疗靶标
2. Transglutaminase 2–Specific Autoantibodies in Celiac Disease Target Clustered, N-Terminal Epitopes Not Displayed on the Surface of Cells [J] . Rasmus Iversen, Roberto Di Niro, Jorunn Stamnaes, The journal of immunology . 2013,第12期

机译：转谷氨酰胺酶2 –腹腔疾病的特异性自身抗体靶向聚集在细胞表面的N末端抗原决定簇
3. Transglutaminase 2-targeted autoantibodies in celiac disease: Pathogenetic players in addition to diagnostic tools? [J] . Lindfors K, Maki M, Kaukinen K Autoimmunity reviews . 2010,第11期

机译：腹腔疾病中转谷氨酰胺酶2靶向的自身抗体：除了诊断工具外，还可以是致病因素？
4. Novel Target Class: microRNA in Human Disease and Development miRNA as Diagnostic Biomarkers and Targets for Therapeutic Development - MicroRNAs and Their Prospective Roles in Disease Development [C] . James Xia Annual Meeting of the Cambridge Healthtech Institute . 2005

机译：新型靶阶级：人类疾病和发育miRNA的MicroRNA作为诊断生物标志物和治疗发育的目标 - MicroRNA和疾病发展的前瞻性作用
5. Multi-Compartmental Oral Delivery Systems for Silencing Intestinal Tissue Transglutaminase-2 and Interleukin-15 Genes in the Treatment of Celiac Disease. [D] . Attarwala, Husain. 2016

机译：多室口服递送系统，用于沉默肠组织转谷氨酰胺酶2和白介素15基因，治疗乳糜泻。
6. The Intestinal T Cell Response to α-Gliadin in Adult Celiac Disease Is Focused on a Single Deamidated Glutamine Targeted by Tissue Transglutaminase [O] . Helene Arentz-Hansen, Roman Körner, Øyvind Molberg, 2000

机译：成人乳糜泻对α-麦醇溶蛋白的肠道T细胞反应集中在以组织转谷氨酰胺酶为靶标的单个脱酰胺的谷氨酰胺上
7. Tissue Transglutaminase Is the Target in Both Rodent and Primate Tissues for Celiac Disease - Specific Autoantibodies [O] . Korponay-Szabó Ilma, Sulkanen Satu, Halttunen Tuula, 2017

机译：组织转谷氨酰胺酶是乳鼠疾病特异性自身抗体的啮齿动物和灵长类组织的靶标

Transglutaminase as a therapeutic target for celiac disease

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