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首页> 外文期刊>Expert opinion on therapeutic targets >Gap junctions and connexins as therapeutic targets in cancer.
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Gap junctions and connexins as therapeutic targets in cancer.

机译：间隙连接和连接蛋白作为癌症的治疗靶标。

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IMPORTANCE OF THE FIELD: Connexins (Cxs) and gap junctional intercellular communications (GJICs) play roles in cancer development, growth and metastasis. Experimental studies suggest that targeting Cxs may be a novel technique, either to inhibit tumor cell growth directly or to sensitize to various therapies. AREAS COVERED IN THIS REVIEW: A brief introduction to the role of Cxs in cancer. The focus is mainly on data available in the literature regarding therapeutic aspects. WHAT THE READER WILL GAIN: This article reviews the various strategies that take advantage of gap junctions and connexins to eliminate cancer cells, including use of the bystander effect (BE) in gene therapy, the effect of connexins on chemosensitization, the role of apoptotic processes and interactions with the microenvironment. Attempts to restore connexin expression at the transcriptional and post-transcriptional levels are described, as well as promising strategies recently explored. The potential and limitations of the approaches are discussed. TAKE HOME MESSAGE: Connexins have multiple facets, singly, in hemichannel complexes, in gap junctions or interacting with different proteins. The regulation of their expression is not fully resolved and selective manipulation of Cxs expression is therefore a challenge. Although the therapeutic potential of connexins is undeniable, more effort is needed to study the regulation and functions of these proteins.
机译：领域的重要性：连接蛋白（Cxs）和间隙连接细胞间通讯（GJIC）在癌症的发展，生长和转移中发挥着作用。实验研究表明，靶向Cxs可能是一种新颖的技术，既可以直接抑制肿瘤细胞的生长，也可以使其对各种疗法敏感。这篇综述涵盖的领域：Cxs在癌症中的作用的简要介绍。重点主要在于文献中有关治疗方面的可用数据。读者将获得什么：本文回顾了利用缺口连接和连接蛋白消除癌细胞的各种策略，包括在基因疗法中使用旁观者效应（BE），连接蛋白对化学增敏的作用，凋亡过程的作用。以及与微环境的相互作用。描述了在转录和转录后水平恢复连接蛋白表达的尝试，以及最近探索的有希望的策略。讨论了这些方法的潜力和局限性。温馨提示：连接蛋白在半通道复合物中，在缝隙连接处或与不同蛋白质相互作用时，具有多个方面。它们表达的调节尚未完全解决，因此对Cxs表达的选择性操纵是一个挑战。尽管连接蛋白的治疗潜力是不可否认的，但是需要更多的努力来研究这些蛋白的调节和功能。

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