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Targeting IL-23 in human diseases.

机译：针对人类疾病的IL-23。

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IMPORTANCE OF THE FIELD: IL-23 is one of the most intriguing cytokine for its many immunological functions, which are the basis of its important role in host defense but also of its possible contribution to the pathogenesis of several diseases. AREAS COVERED IN THIS REVIEW: The literature and patents about IL-23 pathway and their targeting in therapeutic potential applications. Findings published within the last 5 years receive particular attention. WHAT THE READER WILL GAIN: An overview of the emerging role of IL-23 in physiological and pathological conditions and a review of the different approaches (IL-23 pathway-based) currently used for autoimmune diseases and cancer therapies and the results obtained both in preclinical models and in clinical trials. TAKE HOME MESSAGE: Inhibition/targeting of IL-23 may be a good and novel therapeutic strategy, especially in the treatment of diseases like psoriasis, for which current treatments show more pronounced side effects than those of IL-23-blocking and employed as part of specific patient-tailored therapies in inflammatory bowel diseases.
机译：领域的重要性：IL-23具有许多免疫功能，是最令人着迷的细胞因子之一，这是其在宿主防御中的重要作用的基础，也是其在多种疾病的发病机理中的可能基础。本文涵盖的领域：关于IL-23途径及其在治疗潜在应用中的靶向作用的文献和专利。最近5年内发表的发现受到特别关注。读者将获得什么：IL-23在生理和病理状况中新兴作用的概述，以及当前用于自身免疫性疾病和癌症治疗的不同方法（基于IL-23途径的方法）的综述，以及在临床前模型和临床试验。温馨提示：抑制/靶向IL-23可能是一种好的且新颖的治疗策略，尤其是在牛皮癣等疾病的治疗中，针对这种疾病，目前的治疗方法显示出比IL-23阻断剂更明显的副作用，并已作为一部分治疗方法。在炎症性肠病中针对患者的特定疗法。

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