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Targeting the Notch signaling pathway in autoimmune diseases.

机译：针对自身免疫性疾病中的Notch信号通路。

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IMPORTANCE OF THE FIELD: The Notch signaling pathway regulates a variety of processes and has been linked to diverse effects. Aberrant Notch function is important in several disorders. Pre-clinical studies have suggested that inhibition of Notch is an attractive approach to treat hematologic and solid malignancies. Many patients with refractory autoimmune diseases respond poorly to therapy and have significant morbidity and the treatment is highly toxic, so more effective therapies for autoimmune diseases are being examined. AREAS COVERED IN THIS REVIEW: The role of the Notch pathway and therapeutic strategies targeting it in many illnesses, especially autoimmune diseases. WHAT THE READER WILL GAIN: The Notch pathway has unique and attractive advantages for targeting. Targeting it has already been trialed in many experiments, which may show better efficacy and fewer side effects compared with classical drugs for the treatment. Targeting Notch might provide etiological rather than symptomatic treatment. TAKE HOME MESSAGE: Various methods targeting the Notch pathway have been under investigation. Rational targeting of the Notch signaling pathway in cancer and some autoimmune diseases has proven to be successful. Classical drugs for the treatment of autoimmune diseases are inefficient and toxic to some extent, and targeting the Notch pathway is a promising therapeutic concept. However, there are still many questions about targeting Notch in autoimmune diseases, and further investigation will be needed.
机译：领域的重要性：Notch信号通路调节多种过程，并与多种作用相关。 Notch异常功能在几种疾病中很重要。临床前研究表明，抑制Notch是治疗血液系统和实体恶性肿瘤的一种有吸引力的方法。许多难治性自身免疫性疾病患者对治疗的反应较差，发病率很高，且治疗毒性很高，因此正在研究针对自身免疫性疾病的更有效疗法。本综述涵盖的领域：Notch途径的作用和针对该途径的治疗策略在许多疾病中，特别是在自身免疫性疾病中。读者所能获得的收益：刻槽途径在靶向方面具有独特而诱人的优势。靶向它已经在许多实验中进行了试验，与经典药物相比，它可能显示出更好的疗效和更少的副作用。针对Notch可能提供病因而不是对症治疗。进行家庭消息：针对Notch途径的各种方法已经在研究中。在癌症和某些自身免疫性疾病中，Notch信号通路的合理靶向已被证明是成功的。用于治疗自身免疫性疾病的经典药物在某种程度上效率低下且有毒，靶向Notch途径是一个有前途的治疗概念。但是，在自身免疫性疾病中靶向Notch仍然存在许多问题，需要进一步研究。

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