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Molecular targets on B-cells to prevent and treat antibody-mediated rejection in organ transplantation. Present and Future

机译:B细胞上的分子靶标可预防和治疗器官移植中抗体介导的排斥反应。现在与未来

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Introduction: Waiting lists for transplant are increasing day after day since transplantation is still the best option for the treatment of end-stage organ failure. Likewise, our increasing knowledge about how immune system mounts the response against allograft is at the point that up to 95% of acute T-cell-mediated rejections are effectively controlled by current immunosuppressive therapy. Nevertheless, this is not the case for acute and chronic antibody-mediated rejections (ABMR), where treatments to reduce the level of donor specific antibodies (DSAs) remain suboptimal, causing the majority of acute and chronic graft losses.
机译:简介:移植的等待清单每天都在增加,因为移植仍然是治疗晚期器官衰竭的最佳选择。同样,我们对免疫系统如何增强针对同种异体移植物的反应的认识越来越多,目前的免疫抑制疗法可有效控制高达95%的急性T细胞介导的排斥反应。但是,对于急性和慢性抗体介导的排斥反应(ABMR)并非如此,在该方法中,降低供体特异性抗体(DSA)水平的治疗仍然欠佳,导致大多数急性和慢性移植物损失。

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