Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD)

Laucho-Contreras Maria E.; Polverino Francesca; Tesfaigzi Yohannes; Pilon Aprile; Celli Bartolome R.; Owen Caroline A.

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Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD)

机译：俱乐部细胞蛋白16（CC16）增强：慢性阻塞性肺疾病（COPD）的潜在疾病改良方法。

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Introduction: Club cell protein 16 (CC16) is the most abundant protein in bronchoalveolar lavage fluid. CC16 has anti-inflammatory properties in smoke-exposed lungs, and chronic obstructive pulmonary disease (COPD) is associated with CC16 deficiency. Herein, we explored whether CC16 is a therapeutic target for COPD.

机译：简介：俱乐部细胞蛋白16（CC16）是支气管肺泡灌洗液中含量最高的蛋白。 CC16在暴露于烟雾的肺部具有抗炎特性，而慢性阻塞性肺疾病（COPD）与CC16缺乏有关。在本文中，我们探讨了CC16是否是COPD的治疗靶标。

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《Expert opinion on therapeutic targets》 |2016年第7期|共15页
作者
Laucho-Contreras Maria E.; Polverino Francesca; Tesfaigzi Yohannes; Pilon Aprile; Celli Bartolome R.; Owen Caroline A.;
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正文语种 eng
中图分类药学;
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Bronchoalveolar lavage fluid; CC10; CC16; chronic bronchitis; Club cells; COPD; emphysema; formyl peptide receptor-2; lipoxin A(4); lung inflammation; nuclear factor kappa B; phospholipase A(2); recombinant therapy; serum amyloid A; secretoglobin 1A1; small airway remodeling; toll-like receptor; uteroglobin;

机译：支气管肺泡灌洗液;CC10;CC16;慢性支气管炎;俱乐部细胞;COPD;肺气肿;甲酰肽受体-2;脂蛋白A（4）;肺部炎症;核因子κB;磷脂酶A（2）;重组疗法;血清淀粉样蛋白A;分泌球蛋白1A1;小气道重塑;通行费样受体;子宫球蛋白;

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1. Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD) [J] . Laucho-Contreras Maria E., Polverino Francesca, Tesfaigzi Yohannes, Expert opinion on therapeutic targets . 2016,第7期

机译：俱乐部细胞蛋白16（CC16）增强：慢性阻塞性肺疾病（COPD）的潜在疾病改良方法。
2. Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease [J] . Sofie Lock-Johansson, Jorgen Vestbo, Grith Lykke Sorensen Respiratory Research . 2014,第1期

机译：慢性阻塞性肺疾病中表面活性剂蛋白D，俱乐部细胞蛋白16，肺和激活调节的趋化因子，C反应蛋白和纤维蛋白原生物标志物变化
3. Club Cell Protein 16 and Disease Progression in Chronic Obstructive Pulmonary Disease [J] . Hye Yun Park, Andrew Churg, Joanne L. Wright, American journal of respiratory and critical care medicine . 2013,第12期

机译：俱乐部细胞蛋白16与慢性阻塞性肺疾病的疾病进展
4. CHRONIOUS: An open, ubiquitous and adaptive chronic disease management platform for Chronic Obstructive Pulmonary Disease (COPD), Chronic Kidney Disease (CKD) and renal insufficiency [C] . Rosso R., Munaro G., Salvetti O., 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2010

机译：慢性病：针对慢性阻塞性肺疾病（COPD），慢性肾脏病（CKD）和肾功能不全的开放，无处不在的适应性慢性疾病管理平台
5. Human anti-histone 3.3 antibodies as potential biotherapeutics for Chronic Obstructive Pulmonary Disease (COPD). [D] . Pang, Yu. 2016

机译：人类抗组蛋白3.3抗体可作为慢性阻塞性肺疾病（COPD）的潜在生物疗法。
6. Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD) [O] . Maria E. Laucho-Contreras, Francesca Polverino, Yohannes Tesfaigzi, -1

机译：俱乐部细胞蛋白16（CC16）增强：慢性阻塞性肺疾病（COPD）的潜在疾病改良方法。
7. Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD) [O] . Maria E. Laucho-Contreras, Francesca Polverino, Yohannes Tesfaigzi, 2016

机译：俱乐部细胞蛋白质16（CC16）增强：慢性阻塞性肺病（COPD）的潜在疾病改性方法

Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD)

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