P2X7-induced apoptosis decreases by aging in mice myeloblasts.

Paredes-Gamero EJ; Dreyfuss JL; Nader HB; Miyamoto-Oshiro ME; Ferreira AT

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P2X7-induced apoptosis decreases by aging in mice myeloblasts.

机译：P2X7诱导的凋亡通过小鼠成肌细胞衰老而减少。

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In the current study, the ability of ATP to promote apoptosis in myeloblasts at different ages was investigated. We have observed that high concentration of extracellular ATP (>1mM), which activates P2X(7) receptor, produced cell shrinkage an increase in the number of events in the sub-G(0)/G(1) region of the cellular cycle and annexin-V/propidium iodide label, which characterizes the apoptotic cell death. In addition, BzATP produced apoptosis, but not ADP and UTP. Gr-1(+) cells express the P2X(7) receptor and oxidized ATP, a specific P2X(7) inhibitor, blocked the ATP-dependent apoptosis. ATP-dependent apoptosis is decreased by aging in myeloblasts of 12 and 22-month-old mice. Furthermore, P2X(7) expression decrease was observed in older mice, explaining apoptosis decrease. This decrease in apoptosis by aging may be related to some diseases in the myelocyte lineage.

机译：在当前的研究中，研究了ATP促进不同年龄成肌细胞凋亡的能力。我们已经观察到高浓度的激活P2X（7）受体的细胞外ATP（> 1mM），导致细胞萎缩，导致细胞周期sub-G（0）/ G（1）区域中事件数量增加和膜联蛋白-V /碘化丙啶标记，其表征细胞凋亡。另外，BzATP产生凋亡，但不产生ADP和UTP。 Gr-1（+）细胞表达P2X（7）受体和氧化的ATP，一种特定的P2X（7）抑制剂，阻断了ATP依赖性细胞凋亡。在12和22个月大的小鼠的成纤维细胞中，ATP依赖的凋亡会因衰老而减少。此外，在老年小鼠中观察到P2X（7）表达下降，这说明细胞凋亡减少。衰老引起的凋亡减少可能与骨髓细胞谱系中的某些疾病有关。

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来源
《Experimental Gerontology》 |2007年第4期|共7页
作者
Paredes-Gamero EJ; Dreyfuss JL; Nader HB; Miyamoto-Oshiro ME; Ferreira AT;
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正文语种 eng
中图分类老年病学;
关键词
Apoptosis; Laboratory mice; Azathioprine; Aging; receptor; 脱噬作用; 硫唑嘌呤; 衰老;

机译：Apoptosis;Laboratory mice;Azathioprine;Aging;receptor;脱噬作用;硫唑嘌呤;衰老;

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P2X7-induced apoptosis decreases by aging in mice myeloblasts.

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