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首页> 外文期刊>Expert opinion on therapeutic targets >A short commentary on the review by Weller and Kuchta: The DNA helicase-primase complex as a target for herpes virus infection
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A short commentary on the review by Weller and Kuchta: The DNA helicase-primase complex as a target for herpes virus infection

机译：关于Weller和Kuchta的评论的简短评论：DNA解旋酶-引发酶复合物可作为疱疹病毒感染的靶标

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摘要

For anyone new to the field of herpes virus DNA replication may I point you to the perfect introduction to this subject by the doyenne of herpes virus helicase-primase, Sandra K Weller and her co-author, Robert D Kuchta [i]. This is not only an 'expert' opinion in every sense but is also a lucid and readable account that brings a potentially rather dry subject to life. The work of Weller over more than 20 years on DNA-replication protein-protein interactions has made a major impact on our understanding of the role of helicase-primase in herpes virus DNA replication. The elucidation of the complexities of the communication between several multi-meric virus-coded proteins and herpes virus DNA and how the virus both uses and depresses cellular responses to the invading virus has encouraged several pharmaceutical companies to seek selective inhibitors of the helicase-primase (HPI) functions. A small number of drug candidates have come to the fore, and over the last couple of years, two HPI (amenamevir and pritelivir) have commenced clinical trials. This review puts these recent therapeutic candidates of HPI in the context of more familiar nucleoside analog inhibitors such as acyclovir and penciclovir that target DNA polymerase.
机译：对于疱疹病毒DNA复制领域的任何新手，我想向您介绍疱疹病毒解旋酶-引发酶的多耶宁（Sandra K Weller）和她的合著者Robert D Kuchta [i]。这不仅是每种意义上的“专家”意见，而且还是一种清晰易读的叙述，将潜在的相当枯燥的主题带入生活。 Weller在DNA复制蛋白相互作用方面超过20年的工作对我们理解解旋酶-引发酶在疱疹病毒DNA复制中的作用产生了重大影响。为阐明几种多聚体病毒编码蛋白与疱疹病毒DNA之间的通讯复杂性以及该病毒如何利用和抑制对入侵病毒的细胞反应，鼓励了多家制药公司寻求选择性的解旋酶-酶抑制剂（ HPI）功能。少数候选药物脱颖而出，并且在最近几年中，两种HPI（阿美那韦和吡咯韦韦）已经开始临床试验。这篇综述将HPI的这些最新治疗候选物与靶向DNA聚合酶的更熟悉的核苷类似物抑制剂（例如无环鸟苷和喷昔洛韦）联系起来。

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