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Surface plasmon resonance-induced photoactivation of gold nanoparticles as mitochondria-targeted therapeutic agents for pancreatic cancer

机译：表面等离振子共振诱导的金纳米粒子的光活化作为线粒体靶向治疗胰腺癌的治疗剂

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Background: Noble metal nanoparticles such as gold nanoparticles can strongly absorb light in the visible region by inducing coherent collective oscillation of conduction band electrons in strong resonance with visible frequencies of light. This phenomenon is frequently termed as surface plasmon resonance (SPR). Objectives: The main objective was to study the effects of laser photoactivated gold nanoparticles (by means of SPR) on human pancreatic cancer cells. Results: Gold nanoparticles obtained using standard wet chemical methods (with sodium borohydride as a reducing agent) underwent photoexcitation using 2w 808 nm laser and further administered to 1.4E7 pancreatic cancer cell lines. Flow cytometry, transmission electron microscopy, phase contrast microscopy, quantitative proteomics and confocal microscopy combined with immunochemical staining were used to examine the interaction between photo excited gold nanoparticles and pancreatic cancer cells. Conclusion: The study shows that phonon-phonon interactions following laser photoexcitation of gold nanoparticles exhibit increased intracellular uptake, as well as mitochondrial swelling, closely followed by mitochondrial inner membrane permeabilization and depolarization. This unique data may represent a major step in mitochondria-targeted anticancer therapies using laser-activated gold nanoparticles.
机译：背景：贵金属纳米粒子（例如金纳米粒子）可以通过在可见光频率下以强共振方式诱导导带电子的相干集体振荡来强烈吸收可见光。这种现象通常被称为表面等离子体共振（SPR）。目的：主要目的是研究激光光活化金纳米颗粒（通过SPR）对人胰腺癌细胞的影响。结果：使用2w 808 nm激光对使用标准湿化学方法（使用硼氢化钠作为还原剂）获得的金纳米颗粒进行光激发，然后将其进一步施用于1.4E7胰腺癌细胞系。流式细胞仪，透射电镜，相差显微镜，定量蛋白质组学和共聚焦显微镜结合免疫化学染色被用来检查光激发金纳米粒子和胰腺癌细胞之间的相互作用。结论：研究表明，金纳米粒子的激光光激发后，声子-声子相互作用表现出增加的细胞内摄取以及线粒体膨胀，紧接着是线粒体内膜透化和去极化。这一独特的数据可能代表了使用激光激活的金纳米颗粒的线粒体靶向抗癌治疗的重要一步。

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