Pyruvate dehydrogenase as a therapeutic target for obesity cardiomyopathy

Lewis Andrew J. M.; Neubauer Stefan; Tyler Damian J.; Rider Oliver J.

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Pyruvate dehydrogenase as a therapeutic target for obesity cardiomyopathy

机译：丙酮酸脱氢酶作为肥胖型心肌病的治疗靶标

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Introduction: Obesity cardiomyopathy is a major public health problem with few specific therapeutic options. Abnormal cardiac substrate metabolism with reduced pyruvate dehydrogenase (PDH) activity is associated with energetic and functional cardiac impairment and may be a therapeutic target.

机译：简介：肥胖型心肌病是一个主要的公共健康问题，几乎没有特定的治疗选择。丙酮酸脱氢酶（PDH）活性降低的心脏底物代谢异常与精力充沛和功能性心脏损害相关，可能是治疗目标。

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《Expert opinion on therapeutic targets》 |2016年第6期|共12页
作者
Lewis Andrew J. M.; Neubauer Stefan; Tyler Damian J.; Rider Oliver J.;
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正文语种 eng
中图分类药学;
关键词
Obesity; heart failure; metabolism; imaging;

机译：肥胖;心力衰竭;新陈代谢;影像学;

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1. Pyruvate dehydrogenase as a therapeutic target for obesity cardiomyopathy [J] . Lewis Andrew J. M., Neubauer Stefan, Tyler Damian J., Expert opinion on therapeutic targets . 2016,第6期

机译：丙酮酸脱氢酶作为肥胖型心肌病的治疗靶标
2. THERAPEUTIC TARGETING OF THE PYRUVATE DEHYDROGENASE COMPLEX/PYRUVATE DEHYDROGENASE KINASE (PDC/PDK) AXIS FOR CONGENITAL AND ACQUIRED METABOLIC DISEASES [J] . Stacpoole Peter W., Aponick Aaron Molecular genetics and metabolism . 2018,第3期

机译：丙酮酸脱氢酶络合物/丙酮酸脱氢酶激酶（PDC / PDK）轴用于先天性和获得的代谢疾病的治疗靶向
3. THERAPEUTIC TARGETING OF THE PYRUVATE DEHYDROGENASE COMPLEX/PYRUVATE DEHYDROGENASE KINASE (PDC/PDK) AXIS FOR CONGENITAL AND ACQUIRED METABOLIC DISEASES [J] . Stacpoole Peter W., Aponick Aaron Molecular genetics and metabolism . 2018,第3期

机译：丙酮酸脱氢酶络合物/丙酮酸脱氢酶激酶（PDC / PDK）轴用于先天性和获得的代谢疾病的治疗靶向
4. Safety Concerns of Anti-obesity Drugs and Current Therapeutic Targets [C] . Chandi S. Elanqbam Annual Meeting of the American Society for Veterinary Clinical Pathology . 2007

机译：抗肥胖药物和目前治疗目标的安全问题
5. Novel Obesity Suppressor Function of the Retinoblastoma Protein Uncovers Cyclindependent Kinase 4 as a Therapeutic Target for Diet-Induced Obesity [D] . Iqbal, Niloy Jafar. 2019

机译：视网膜母细胞瘤蛋白的新型肥胖抑制函数揭示环依赖性激酶4作为饮食诱导肥胖的治疗靶标
6. Hyperpolarized 13C and 31P magnetic resonance spectroscopy identify pyruvate dehydrogenase as a therapeutic target in obesity cardiomyopathy [O] . Andrew J Lewis, Michael S Dodd, Joevin Sourdon, 2015

机译：超极化13C和31P磁共振波谱确定丙酮酸脱氢酶是肥胖型心肌病的治疗靶标
7. Hyperpolarized C and P magnetic resonance spectroscopy identify pyruvate dehydrogenase as a therapeutic target in obesity cardiomyopathy [O] . 2015

机译：超极化C和P磁共振波谱确定丙酮酸脱氢酶是肥胖型心肌病的治疗靶标

Pyruvate dehydrogenase as a therapeutic target for obesity cardiomyopathy

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