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首页> 外文期刊>Expert opinion on therapeutic targets >Possible drug targets for celiac disease.
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Possible drug targets for celiac disease.

机译：腹腔疾病的可能药物靶标。

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Celiac disease (CD) is an intestinal disorder caused by an altered immune response against wheat gluten, a common dietary antigen, and related cereal proteins. Both CD4+ and CD8+ T cells have a role in inducing the intestinal damage, although recent studies have also pinpointed the involvement of the innate immune response in CD pathogenesis. So far, the only available treatment for CD is the strict avoidance of gluten in the diet, but the poor compliance and the associated complications demand alternative therapies. During the last decade, the knowledge of genetic, molecular and cellular mechanisms leading to CD pathogenesis made great progress. The improved understanding of gluten peptides activating either adaptive or innate immune response, of HLA restriction molecules, as well as of cytokines that mediate most of the inflammatory reactions, opens several new promising perspectives for therapeutic intervention. This review discusses both molecular and cellular strategies to treat CD, including the use of proteolytic enzymes active on gluten peptides, antibodies neutralising IL-15 and IFN-gamma, drugs targeting HLA, regulatory cytokines and T cells.
机译：乳糜泻（CD）是一种肠道疾病，由针对小麦面筋，一种常见的饮食抗原和相关谷类蛋白质的免疫反应改变引起。 CD4 +和CD8 + T细胞均具有诱导肠道损伤的作用，尽管最近的研究也指出了先天免疫应答与CD发病机制有关。到目前为止，唯一可用于CD的治疗方法是严格避免饮食中的麸质，但是依从性差和相关的并发症需要替代疗法。在过去的十年中，导致CD发病机理的遗传，分子和细胞机制的知识取得了长足的进步。对激活激活适应性或先天性免疫应答的面筋肽，HLA限制分子以及介导大多数炎症反应的细胞因子的进一步了解为治疗性干预开辟了一些新的有希望的前景。这篇综述讨论了治疗CD的分子和细胞策略，包括使用对麸质肽有活性的蛋白水解酶，中和IL-15和IFN-γ的抗体，靶向HLA的药物，调节性细胞因子和T细胞。

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