• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Expert opinion on therapeutic targets >A final common pathway for depression: implications for therapy.
【24h】

A final common pathway for depression: implications for therapy.

机译：抑郁症的最终共同途径：对治疗的意义。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Depression in humans and animal models has been found to be accompanied by a hypoactivity of brain regions involved in positively motivated behavior together with a hyperactivity in regions involved in stress responses. Both sets of changes are reversed by diverse antidepressant treatments. It has been proposed that this neural pattern underlies the symptoms common to most forms of depression, which are the loss of positively motivated behavior and the increase in stress. The present paper discusses how this framework can organize diverse findings on the multiple factors associated with this disorder. The hypothesis suggests new therapeutic strategies involving treatment with low-dose corticosteroids to suppress the stress network or with antagonists of alpha(1A)- and agonists of alpha(1B)-adrenoceptors to disinhibit or activate the positive motivational network, respectively.
机译：已经发现，在人类和动物模型中的抑郁症伴随着大脑中参与积极动机行为的区域活动不足，以及参与应激反应的区域活动过度。两组变化均通过多种抗抑郁药治疗得以逆转。已经提出，这种神经模式是大多数抑郁症常见的症状的基础，这些症状是丧失积极动机的行为和压力增加。本文讨论了该框架如何组织与该疾病相关的多种因素的不同发现。假说提出了新的治疗策略，涉及用低剂量皮质类固醇抑制压力网络或用α（1A）-拮抗剂和α（1B）-肾上腺素受体激动剂分别抑制或激活积极的动机网络。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号