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首页> 外文期刊>Expert opinion on therapeutic targets >Toll-like receptors as therapeutic targets in cystic fibrosis.
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Toll-like receptors as therapeutic targets in cystic fibrosis.

机译：Toll样受体作为囊性纤维化的治疗靶标。

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Background: Toll-like receptors (TLRs) are pattern recognition receptors that act as a first-line of defence in the innate immune response by recognising and responding to conserved molecular patterns in microbial factors and endogenous danger signals. Cystic fibrosis (CF)-affected airways represent a milieu potentially rich in TLR agonists and the chronic inflammatory phenotype evident in CF airway epithelial cells is probably due in large part to activation of TLRs. Objective/methods: To examine the prospects of developing novel therapies for CF by targeting TLRs. We outline the expression and function of TLRs and explore the therapeutic potential of naturally-occurring and synthetic TLR inhibitors for CF. Results/conclusion: Modulation of TLRs has therapeutic potential for the inflammatory lung manifestations of CF.
机译：背景：Toll样受体（TLR）是模式识别受体，通过识别和响应微生物因子和内源性危险信号中的保守分子模式，在先天性免疫反应中充当防御的第一线。受囊性纤维化（CF）影响的气道代表了可能富含TLR激动剂的环境，并且CF气道上皮细胞中明显的慢性炎症表型可能很大程度上是由于TLR的激活所致。目的/方法：考察通过靶向TLRs开发CF新疗法的前景。我们概述了TLR的表达和功能，并探讨了天然存在的和合成的TLR抑制剂对CF的治疗潜力。结果/结论：TLR的调节对CF的炎症性肺表现具有治疗潜力。

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