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A consideration of some notable aging theories.

机译:考虑一些著名的老化理论。

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摘要

Aging is characterized as a breakdown process and the relevant events occur after reproduction, when the force of natural selection declines. Studies on the life histories of species reveal that there is an association between resource allocation and longevity and that the aging process is retarded when animals are protected from the deleterious consequences of excess metabolic activity. Although the extent to which aging is caused by environmental or genetic factors is unresolved, our understanding of the field has been enriched by the rapid development of the tools of molecular biology. In his pioneering work, Alex Comfort has postulated a hierarchical clock system as a descriptive paradigm of the aging process, and investigations at the molecular level are bringing to light evidence of a genetic link to life span that seems consistent with Comfort's model. It appears however, that the appropriate context for these mechanistic observations of functional decline is in the postreproductive period.
机译:衰老的特征是分解过程,当自然选择力下降时,相关事件就会在繁殖后发生。有关物种生命史的研究表明,资源分配与寿命之间存在关联,并且当保护动物免受过度代谢活动的有害后果时,衰老过程会受到阻碍。尽管由环境或遗传因素导致的衰老程度尚未得到解决,但是分子生物学工具的迅速发展使我们对该领域的理解更加丰富。在他的开创性工作中,亚历克斯·康福特(Alex Comfort)提出了一种分层的时钟系统作为衰老过程的描述范例,并且在分子水平上的研究揭示了与康福特的模型之间存在遗传联系的证据。然而,似乎这些功能性下降的机械观察的适当背景是在生殖后时期。

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