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Novel therapeutic targets in Helicobacter pylori.

机译:幽门螺杆菌中的新型治疗靶标。

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The failure of current regimens to treat the gastric pathogen Helicobacter pylori is a growing problem. Responsible for gastritis and peptic ulcer disease, and designated as a Class 1 carcinogen, its presence in up to 90% of the population of the developing world makes its treatment a primary concern. The use of genomic, proteomic and transcriptomic data to determine essential gene products as targets for novel therapeutic agents is of key interest in this research. This review describes how such data can be obtained, evaluated and eventually used as a basis for the development of both vaccine and novel anti-helicobacter agents. It indicates both past successes and possible new avenues to exploit the increased availability of such data, whilst also examining the limitations of such approaches.
机译:当前治疗胃病原体幽门螺杆菌的方案失败是一个日益严重的问题。它负责胃炎和消化性溃疡疾病,被指定为1类致癌物,其在多达90%的发展中国家人口中的存在使它的治疗成为首要问题。利用基因组,蛋白质组和转录组数据确定必需基因产物作为新型治疗剂的靶标,是这项研究的主要兴趣。这篇综述描述了如何获得,评估和最终将这些数据用作开发疫苗和新型抗幽门螺杆菌药物的基础。它既表明了过去的成功,也表明了利用这种数据的日益增加的可能性的新途径,同时还研究了这种方法的局限性。

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